Full Product Name
GFM1 Antibody
Product Gene Name
anti-GFM1 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q96RP9
Concentration
1.0mg/ml (lot specific)
Other Notes
Small volumes of anti-GFM1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-GFM1 antibody
Western Blot (WB)
NCBI/Uniprot data below describe general gene information for GFM1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001295093.1
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NCBI GenBank Nucleotide #
NM_001308164.1
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UniProt Primary Accession #
Q96RP9
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UniProt Secondary Accession #
Q6GTN2; Q96T39; A6NCI9; B2RCB9; B3KRW1[Other Products]
UniProt Related Accession #
Q96RP9[Other Products]
Molecular Weight
85,869 Da
NCBI Official Full Name
elongation factor G, mitochondrial isoform 1
NCBI Official Synonym Full Names
G elongation factor mitochondrial 1
NCBI Official Symbol
GFM1 [Similar Products]
NCBI Official Synonym Symbols
EFG; GFM; EFG1; EFGM; EGF1; hEFG1; COXPD1
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NCBI Protein Information
elongation factor G, mitochondrial
UniProt Protein Name
Elongation factor G, mitochondrial
UniProt Synonym Protein Names
Elongation factor G 1, mitochondrial
UniProt Gene Name
GFM1 [Similar Products]
UniProt Synonym Gene Names
hEFG1 [Similar Products]
NCBI Summary for GFM1
Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory chain-oxidative phosphorylation system and to impaired maintenance of mitochondrial DNA. This gene encodes one of the mitochondrial translation elongation factors. Its role in the regulation of normal mitochondrial function and in different disease states attributed to mitochondrial dysfunction is not known. [provided by RefSeq, Jul 2008]
UniProt Comments for GFM1
Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis.
Research Articles on GFM1
1. In the present study, a nanoparticle modified with EGFP-EGF1 (ENP) was constructed as a multitargeting drug delivery system. The protein binding experiment showed EGFP-EGF1 could bind well to A549 tumor cells and other stromal cells including neo-vascular cells, tumor-associated fibroblasts, and tumor-associated macrophages
Precautions
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Disclaimer
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