A kinase (PRKA) anchor protein (yotiao) 9, ELISA Kit

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C.

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Small volumes of AKAP9 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS2602785 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the A kinase (PRKA) anchor protein (yotiao) 9 (AKAP9) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing AKAP9. The ELISA analytical biochemical technique of the MBS2602785 kit is based on AKAP9 antibody-AKAP9 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect AKAP9 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, AKAP9. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

453,667 Da[Similar Products]

A kinase (PRKA) anchor protein 9

A-kinase anchor protein 9; protein yotiao; protein hyperion; AKAP 120-like protein; AKAP9-BRAF fusion protein; kinase N-associated protein; A-kinase anchor protein 350 kDa; A-kinase anchor protein 450 kDa; protein kinase A anchoring protein 9; A kinase (PRKA) anchor protein (yotiao) 9; protein phosphatase 1, regulatory subunit 45; centrosome- and Golgi-localized PKN-associated protein; centrosome- and golgi-localized protein kinase N-associated protein

A-kinase anchor protein 9

AKAP350; AKAP450; KIAA0803; AKAP-9; AKAP 350; hgAKAP 350; AKAP 450; CG-NAP; PRKA9  [Similar Products]

AKAP9_HUMAN

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternate splicing of this gene results in at least two isoforms that localize to the centrosome and the Golgi apparatus, and interact with numerous signaling proteins from multiple signal transduction pathways. These signaling proteins include type II protein kinase A, serine/threonine kinase protein kinase N, protein phosphatase 1, protein phosphatase 2a, protein kinase C-epsilon and phosphodiesterase 4D3. [provided by RefSeq, Aug 2008]

AKAP9: Binds to type II regulatory subunits of protein kinase A. Scaffolding protein that assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. May be required to maintain the integrity of the Golgi apparatus. Isoform 4 is associated with the N-methyl-D-aspartate receptor and is specifically found in the neuromuscular junction (NMJ) as well as in neuronal synapses, suggesting a role in the organization of postsynaptic specializations. Defects in AKAP9 are the cause of long QT syndrome type 11 (LQT11). Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to excercise or emotional stress. They can present with a sentinel event of sudden cardiac death in infancy. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 7q21-q22

Cellular Component: Golgi apparatus; centrosome; voltage-gated potassium channel complex; pericentriolar material; cytoskeleton; intracellular membrane-bound organelle; cytosol

Molecular Function: protein binding; potassium channel regulator activity; protein complex scaffold; receptor binding

Biological Process: synaptic transmission; transport; organelle organization and biogenesis; spermatogenesis; mitotic cell cycle; G2/M transition of mitotic cell cycle; signal transduction; positive regulation of peptidyl-serine phosphorylation; Sertoli cell development

Disease: Long Qt Syndrome 11

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