Product Name
GABRA4, Blocking Peptide
Full Product Name
GABRA4 Peptide - N-terminal region
Product Gene Name
GABRA4 blocking peptide
[Similar Products]
GABRA4 peptide (MBS3227367) is used for blocking the activity of GABRA4 antibody (MBS3202389)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P48169
Form/Format
Lyophilized powder
Preparation and Storage
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20 degree C. Avoid repeat freeze-thaw cycles.
Other Notes
Small volumes of GABRA4 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
GABRA4 blocking peptide
This is a synthetic peptide designed for use in combination with anti-GABRA4 antibody made
Target Description: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Product Categories/Family for GABRA4 blocking peptide
Peptide
Applications Tested/Suitable for GABRA4 blocking peptide
Western Blot (WB)
NCBI/Uniprot data below describe general gene information for GABRA4. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000800
[Other Products]
NCBI GenBank Nucleotide #
NM_000809
[Other Products]
UniProt Primary Accession #
P48169
[Other Products]
UniProt Related Accession #
P48169[Other Products]
NCBI Official Full Name
gamma-aminobutyric acid receptor subunit alpha-4 isoform 1
NCBI Official Synonym Full Names
gamma-aminobutyric acid type A receptor alpha4 subunit
NCBI Official Symbol
GABRA4 [Similar Products]
NCBI Protein Information
gamma-aminobutyric acid receptor subunit alpha-4
UniProt Protein Name
Gamma-aminobutyric acid receptor subunit alpha-4
UniProt Synonym Protein Names
GABA(A) receptor subunit alpha-4
Protein Family
Gamma-aminobutyric acid receptor
UniProt Gene Name
GABRA4 [Similar Products]
UniProt Entry Name
GBRA4_HUMAN
NCBI Summary for GABRA4
Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. This gene encodes subunit alpha-4, which is involved in the etiology of autism and eventually increases autism risk through interaction with another subunit, gamma-aminobutyric acid receptor beta-1 (GABRB1). Alternatively spliced transcript variants encoding different isoforms have been found in this gene.[provided by RefSeq, Feb 2011]
UniProt Comments for GABRA4
GABRA4: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA4 sub-subfamily.
Protein type: Membrane protein, multi-pass; Transporter, ion channel; Transporter; Channel, chloride; Channel, ligand-gated; Membrane protein, integral
Chromosomal Location of Human Ortholog: 4p12
Cellular Component: postsynaptic membrane; integral to plasma membrane; plasma membrane; cell junction
Molecular Function: chloride channel activity; GABA-A receptor activity; benzodiazepine receptor activity; extracellular ligand-gated ion channel activity
Biological Process: synaptic transmission; central nervous system development; transport; transmembrane transport; gamma-aminobutyric acid signaling pathway
Research Articles on GABRA4
1. These results suggest association between GABRR3 rs832032 polymorphism and the risk for restless legs syndrome , and a modifier effect of GABRA4 rs2229940 on the age of onset of restless legs syndrome .
Precautions
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Disclaimer
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