Full Product Name
ATN1 Antibody
Product Synonym Names
ATN1; Atrophin-1; Dentatorubral-pallidoluysian atrophy protein; DRPL
Product Gene Name
anti-ATN1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P54259
Species Reactivity
Human, Mouse
Specificity
The antibody detects endogenous levels of total ATN1 protein.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1.0 mg/ml (lot specific)
Immunogen Description
Synthesized peptide derived from N-terminal of human ATN1.
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-ATN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ATN1 antibody
Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation By similarity. Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Asn (polyQ) repeats.Nagafuchi S., Nat. Genet. 8:177-182(1994).Onodera O., Am. J. Hum. Genet. 57:1050-1060(1995).Margolis R.L., Brain Res. Mol. Brain Res. 36:219-226(1996).
Product Categories/Family for anti-ATN1 antibody
Total protein Ab
Applications Tested/Suitable for anti-ATN1 antibody
Western Blot (WB)
Application Notes for anti-ATN1 antibody
Western blotting: 1:500~1:3000
Western Blot (WB) of anti-ATN1 antibody
Western blot analysis of extracts from HeLa cells, A549 cells, K562 cells, COLO205 cells and NIH-3T3 cells, using ATN1 antibody.
NCBI/Uniprot data below describe general gene information for ATN1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001007027.1
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NCBI GenBank Nucleotide #
NM_001007026.1
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UniProt Primary Accession #
P54259
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UniProt Secondary Accession #
Q99495; Q99621; Q9UEK7[Other Products]
UniProt Related Accession #
P54259[Other Products]
Molecular Weight
125,414 Da
NCBI Official Full Name
atrophin-1
NCBI Official Synonym Full Names
atrophin 1
NCBI Official Symbol
ATN1 [Similar Products]
NCBI Official Synonym Symbols
B37; HRS; NOD; DRPLA; D12S755E
[Similar Products]
NCBI Protein Information
atrophin-1
UniProt Protein Name
Atrophin-1
UniProt Synonym Protein Names
Dentatorubral-pallidoluysian atrophy protein
UniProt Gene Name
ATN1 [Similar Products]
UniProt Synonym Gene Names
D12S755E; DRPLA [Similar Products]
UniProt Entry Name
ATN1_HUMAN
NCBI Summary for ATN1
Dentatorubral pallidoluysian atrophy (DRPLA) is a rare neurodegenerative disorder characterized by cerebellar ataxia, myoclonic epilepsy, choreoathetosis, and dementia. The disorder is related to the expansion from 7-23 copies to 49-75 copies of a trinucleotide repeat (CAG/CAA) within this gene. The encoded protein includes a serine repeat and a region of alternating acidic and basic amino acids, as well as the variable glutamine repeat. Alternative splicing results in two transcripts variants that encode the same protein. [provided by RefSeq, Feb 2010]
UniProt Comments for ATN1
DRPLA: a protein that interacts with the E3 ubiquitin-protein ligase WWP1 and WWP2. May be involved in the third step of ubiquitin conjugation. Relatively high levels in the brain, ovary, testis and prostate. Lower levels in the liver, thymus and leukocytes. Defects are the cause of the neurodegenerative disorders dentatorubral-pallidoluysian atrophy (DRPLA) and Haw River syndrome (HRS).
Protein type: Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 12p13.31
Cellular Component: nucleoplasm; nuclear matrix; perinuclear region of cytoplasm; cytoplasm; nucleus; cell junction
Molecular Function: protein domain specific binding; protein binding; toxin receptor binding; transcription corepressor activity
Biological Process: neuron apoptosis; cell migration; central nervous system development; transcription, DNA-dependent; toxin metabolic process; negative regulation of transcription from RNA polymerase II promoter; maintenance of cell polarity
Disease: Dentatorubral-pallidoluysian Atrophy
Research Articles on ATN1
1. Juvenile myoclonic epilepsy is not associated with the DRPLA gene in a European population.
Precautions
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