ATN1, Polyclonal Antibody

B37; HRS; NOD; DRPLA; D12S755E

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

The antibody detects endogenous levels of total ATN1 protein.

Antigen affinity purification

In pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

1.2mg/ml (lot specific)

Store at -20 degree C.

Small volumes of anti-ATN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Dentatorubral pallidoluysian atrophy (DRPLA) is a rare neurodegenerative disorder characterized by cerebellar ataxia, myoclonic epilepsy, choreoathetosis, and dementia. The disorder is related to the expansion from 7-23 copies to 49-75 copies of a trinucleotide repeat (CAG/CAA) within this gene. The encoded protein includes a serine repeat and a region of alternating acidic and basic amino acids, as well as the variable glutamine repeat. Alternative splicing results in two transcripts variants that encode the same protein.

Total protein Ab

Immunohistochemistry (IHC)

IHC: 1: 40-200

The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using 46321(ATN1 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200)

The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using 46321(ATN1 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200)

125,414 Da

atrophin 1

atrophin-1

Atrophin-1

D12S755E; DRPLA  [Similar Products]

Dentatorubral pallidoluysian atrophy (DRPLA) is a rare neurodegenerative disorder characterized by cerebellar ataxia, myoclonic epilepsy, choreoathetosis, and dementia. The disorder is related to the expansion from 7-35 copies to 49-93 copies of a trinucleotide repeat (CAG/CAA) within this gene. The encoded protein includes a serine repeat and a region of alternating acidic and basic amino acids, as well as the variable glutamine repeat. Alternative splicing results in two transcripts variants that encode the same protein. [provided by RefSeq, Jul 2016]

Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Asn (polyQ) repeats.

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