Product Name
Filamin A (FLN-A), Antibody
Full Product Name
Phospho-Filamin A (Ser2152) Antibody
Product Synonym Names
ABP-280; ABPX; actin binding protein 280; Actin-binding protein 280; Alpha-filamin; DKFZp434P031; Endothelial actin-binding protein; filamin 1; filamin A, alpha; Filamin-1; Filamin-A; FLN; FLN1; FLNA; FMD; MNS; NHBP; Non-muscle filamin; OPD; OPD1
Product Gene Name
anti-FLN-A antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P21333
Species Reactivity
Human, Mouse, Rat
Specificity
Phospho-Filamin A (Ser2152) Antibody detects endogenous levels of Filamin A only when phosphorylated at Serine 2152
Purity/Purification
Immunogen affinity purified
Form/Format
In phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
A synthesized peptide derived from human Filamin A around the phosphorylation site of Serine 2152
Preparation and Storage
Store at-20 degree C for 1 year
Other Notes
Small volumes of anti-FLN-A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-FLN-A antibody
FLNA a ubiquitous cytoskeletal protein that promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Plays an essential role in embryonic cell migration. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins.
Applications Tested/Suitable for anti-FLN-A antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-FLN-A antibody
WB: 1:500-1:2000
IHC: 1:50-1:200
Western Blot (WB) of anti-FLN-A antibody
Western blot analysis of Filamin A phosphorylation expression in EGF treated 293 whole cell lysates, The lane on the left is treated with the antigen-specific peptide.
NCBI/Uniprot data below describe general gene information for FLN-A. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001104026.1
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NCBI GenBank Nucleotide #
NM_001110556.1
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UniProt Primary Accession #
P21333
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UniProt Secondary Accession #
Q5HY53; Q5HY55; Q8NF52; E9KL45[Other Products]
UniProt Related Accession #
P21333[Other Products]
NCBI Official Full Name
filamin-A isoform 2
NCBI Official Synonym Full Names
filamin A
NCBI Official Symbol
FLNA [Similar Products]
NCBI Official Synonym Symbols
FLN; FMD; MNS; OPD; ABPX; CSBS; CVD1; FGS2; FLN1; NHBP; OPD1; OPD2; XLVD; XMVD; FLN-A; ABP-280
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NCBI Protein Information
filamin-A
UniProt Protein Name
Filamin-A
UniProt Synonym Protein Names
Actin-binding protein 280; ABP-280; Alpha-filamin; Endothelial actin-binding protein; Filamin-1; Non-muscle filamin
Protein Family
Filamin A-interacting protein
UniProt Gene Name
FLNA [Similar Products]
UniProt Synonym Gene Names
FLN; FLN1; FLN-A; ABP-280 [Similar Products]
NCBI Summary for FLN-A
The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]
UniProt Comments for FLN-A
Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance ().
Research Articles on FLN-A
1. The mutations of the FLNA gene were observed in 7 (30.4%) of the 23 patients who with Sporadic periventricular nodular heterotopia.
Precautions
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Disclaimer
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