ATP-binding cassette, sub-family C (CFTR/MRP) , member 6, ELISA Kit

Rat Multidrug resistance-associated protein 6 (ABCC6) ELISA kit; ABC34; ARA; EST349056; MLP1; MOATE; MRP6; PXE; PXE1; URG7; ATP-binding cassette; sub-family C; member 6; anthracycline resistance-associated protein; ATP-binding cassette; sub-family C (CFTR/MRP); member 6

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.

Small volumes of ABCC6 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9338834 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the ATP-binding cassette, sub-family C (CFTR/MRP), member 6 (ABCC6) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ABCC6. The ELISA analytical biochemical technique of the MBS9338834 kit is based on ABCC6 antibody-ABCC6 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ABCC6 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ABCC6. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

164,995 Da

ATP-binding cassette, subfamily C (CFTR/MRP), member 6

multidrug resistance-associated protein 6; MLP-1; MRP-like protein 1; ATP-binding cassette sub-family C member 6; liver multidrug resistance-associated protein 6; ATP-binding cassette, sub-family C (CFTR/MRP), member 6

Multidrug resistance-associated protein 6

Mlp1; Mrp6; MLP-1  [Similar Products]

MRP6_RAT

human homolog acts as a Mg-ATP-dependent efflux pump that transports glutathione S-conjugates and mediates a low level of resistance to some anticancer agents [RGD, Feb 2006]

ABCC6: May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Transports glutathione conjugates as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS). Defects in ABCC6 are the cause of pseudoxanthoma elasticum (PXE). PXE is a disorder characterized by calcification of elastic fibers in skin, arteries and retina that results in dermal lesions with associated laxity and loss of elasticity, arterial insufficiency and retinal hemorrhages leading to macular degeneration. PXE is caused in the overwhelming majority of cases by homozygous or compound heterozygous mutations in the ABCC6 gene (autosomal recessive PXE). Individuals carrying heterozygous mutations express limited manifestations of the pseudoxanthoma elasticum phenotype (autosomal dominant PXE). Defects in ABCC6 are the cause of arterial calcification of infancy, generalized, type 2 (GACI2). GACI2 is a severe autosomal recessive disorder characterized by calcification of the internal elastic lamina of muscular arteries and stenosis due to myointimal proliferation. The disorder is often fatal within the first 6 months of life because of myocardial ischemia resulting in refractory heart failure. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.

Protein type: Membrane protein, integral; Transporter, ABC family; Hydrolase; Membrane protein, multi-pass; Transporter

Cellular Component: membrane; basolateral plasma membrane; apical plasma membrane; integral to membrane; plasma membrane; nucleus; lateral plasma membrane

Molecular Function: ATPase activity, coupled to transmembrane movement of substances; ATPase activity; ATP binding

Biological Process: metabolic process; transmembrane transport

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