Product Name
TRPS1, cDNA Clone
Full Product Name
TRPS1 cDNA Clone
Product Gene Name
TRPS1 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
ATGGTCCGGA AAAAGAACCC CCCTCTGAGA AACGTTGCAA GTGAAGGCGA GGGCCAGATC CTGGAGCCTA TAGGTACAGA AAGCAAGGTA TCTGGAAAGA ACAAAGAATT TTCTGCAGAT CAGATGTCAG AAAATACGGA TCAGAGTGAT GCTGCAGAAC TAAATCATAA GGAGGAACAT AGCTTGCATG TTCAAGATCC ATCTTCTAGC AGTAAGAAGG ACTTGAAAAG CGCAGTTCTG AGTGAGAAGG CTGGCTTCAA TTATGAAAGC CCCAGTAAGG GAGGAAACTT TCCCTCCTTT CCGCATGATG AGGTGACAGA CAGAAATATG TTGGCTTTCT CATCTCCAGC TGCTGGGGGA GTCTGTGAGC CCTTGAAGTC TCCGCAAAGA GCAGAGGCAG ATGACCCTCA AGATATGGCC TGCACCCCCT CAGGGGACTC ACTGGAGACA AAGGAAGATC AGAAGATGTC ACCAAAGGCT ACAGAGGAAA CAGGGCAAGC ACAGAGTGGT CAAGCCAATT GTCAAGGTTT GAGCCCAGTT TCAGTGGCCT CAAAAAACCC ACAAGTGCCT TCAGATGGGG GTGTAAGACT GAATAAATCC AAAACTGACT TACTGGTGAA TGACAACCCA GACCCGGCAC CTCTGTCTCC AGAGCTTCAG GACTTTAAAT GCAATATCTG TGGATATGGT TACTACGGCA ACGACCCCAC AGATCTGATT AAGCACTTCC GAAAGTATCA CTTAGGACTG CATAACCGCA CCAGGCAAGA TGCTGAGCTG GACAGCAAAA TCTTGGCCCT TCATAACATG GTGCAGTTCA GCCATTCCAA AGACTTCCAG AAGGTCAACC GTTCTGTGTT TTCTGGTGTG CTGCAGGACA TCAATTCTTC AAGGCCTGTT TTACTAAATG GGACCTACGA TGTGCAGGTG ACTTCAGGTG GAACATTCAT TGGCATTGGA CGGAAAACAC CAGATTGCCA AGGGAACACC AAGTATTTCC GCTGTAAATT CTGCAATTTC ACTTATATGG GCAATTCATC CACCGAATTA GAACAACATT TTCTTCAGAC TCACCCAAAC AAAATAAAAG CTTCTCTCCC CTCCTCTGAG GTTGCAAAAC CTTCAGAGAA AAACTCTAAC AAGTCCATCC CTGCACTTCA ATCCAGTGAT TCTGGAGACT TGGGAAAATG GCAGGACAAG ATAACAGTCA AAGCAGGAGA TGACACTCCT GTTGGGTACT CAGTGCCCAT AAAGCCCCTC GATTCCTCTA GACAAAATGG TACAGAGGCC ACCAGTTACT ACTGGTGTAA ATTTTGTAGT TTCAGCTGTG AGTCATCTAG CTCACTTAAA CTGCTAGAAC ATTATGGCAA GCAGCACGGA GCAGTGCAGT CAGGCGGCCT TAATCCAGAG TTAAATGATA AGCTTTCCAG GGGCTCTGTC ATTAATCAGA ATGATCTAGC CAAAAGTTCA GAAGGAGAGA CAATGACCAA GACAGACAAG AGCTCGAGTG GGGCTAAAAA GAAGGACTTC TCCAGCAAGG GAGCCGAGGA TAATATGGTA ACGAGCTATA ATTGTCAGTT CTGTGACTTC CGATATTCCA AAAGCCATGG CCCTGATGTA ATTGTAGTGG GGCCACTTCT CCGTCATTAT CAACAGCTCC ATAACATTCA CAAGTGTACC ATTAAACACT GTCCATTCTG TCCCAGAGGA CTTTGCAGCC CAGAAAAGCA CCTTGGAGAA ATTACTTATC CGTTTGCTTG TAGAAAAAGT AATTGTTCCC ACTGTGCACT CTTGCTTCTG CACTTGTCTC CTGGGGCGGC TGGAAGCTCG CGAGTCAAAC ATCAGTGCCA TCAGTGTTCA TTCACCACCC CTGACGTAGA TGTACTCCTC TTTCACTATG AAAGTGTGCA TGAGTCCCAA GCATCGGATG TCAAACAAGA AGCAAATCAC CTGCAAGGAT CGGATGGGCA GCAGTCTGTC AAGGAAAGCA AAGAACACTC ATGTACCAAA TGTGATTTTA TTACCCAAGT GGAAGAAGAG ATTTCCCGAC ACTACAGGAG AGCACACAGC TGCTACAAAT GCCGTCAGTG CAGTTTTACA GCTGCCGATA CTCAGTCACT ACTGGAGCAC TTCAACACTG TTCACTGCCA GGAACAGGAC ATCACTACAG CCAACGGCGA AGAGGACGGT CATGCCATAT CCACCATCAA AGAGGAGCCC AAAATTGACT TCAGGGTCTA CAATCTGCTA ACTCCAGACT CTAAAATGGG AGAGCCAGTT TCTGAGAGTG TGGTGAAGAG AGAGAAGCTG GAAGAGAAGG ACGGGCTCAA AGAGAAAGTT TGGACCGAGA GTTCCAGTGA TGACCTTCGC AATGTGACTT GGAGAGGGGC AGACATCCTG CGGGGGAGTC CGTCATACAC CCAAGCAAGC CTGGGGCTGC TGACGCCTGT GTCTGGCACC CAAGAGCAGA CAAAGACTCT AAGGGATAGT CCCAATGTGG AGGCCGCCCA TCTGGCGCGA CCTATTTATG GCTTGGCTGT GGAAACCAAG GGATTCCTGT AG
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of TRPS1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for TRPS1. It may not necessarily be applicable to this product.
NCBI Accession #
BC125020
[Other Products]
UniProt Secondary Accession #
Q08AU2; Q9NWE1; Q9UHH6; B4E1Z5[Other Products]
UniProt Related Accession #
Q9UHF7[Other Products]
Molecular Weight
141,981 Da
NCBI Official Full Name
Homo sapiens trichorhinophalangeal syndrome I, mRNA
NCBI Official Synonym Full Names
transcriptional repressor GATA binding 1
NCBI Official Symbol
TRPS1 [Similar Products]
NCBI Official Synonym Symbols
GC79; LGCR
[Similar Products]
NCBI Protein Information
zinc finger transcription factor Trps1
UniProt Protein Name
Zinc finger transcription factor Trps1
UniProt Synonym Protein Names
Tricho-rhino-phalangeal syndrome type I protein; Zinc finger protein GC79
Protein Family
Tryptophan--tRNA ligase
UniProt Gene Name
TRPS1 [Similar Products]
UniProt Entry Name
TRPS1_HUMAN
NCBI Summary for TRPS1
This gene encodes a transcription factor that represses GATA-regulated genes and binds to a dynein light chain protein. Binding of the encoded protein to the dynein light chain protein affects binding to GATA consensus sequences and suppresses its transcriptional activity. Defects in this gene are a cause of tricho-rhino-phalangeal syndrome (TRPS) types I-III. [provided by RefSeq, Jul 2008]
UniProt Comments for TRPS1
TRPS1: Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes. Defects in TRPS1 are the cause of tricho-rhino-phalangeal syndrome type 1 (TRPS1). TRPS1 is an autosomal dominant disorder characterized by craniofacial and skeletal abnormalities. It is allelic with tricho-rhino-phalangeal type 3. Typical features include sparse scalp hair, a bulbous tip of the nose, protruding ears, a long flat philtrum and a thin upper vermilion border. Skeletal defects include cone-shaped epiphyses at the phalanges, hip malformations and short stature. Defects in TRPS1 are a cause of tricho-rhino-phalangeal syndrome type 2 (TRPS2). A syndrome that combines the clinical features of trichorhinophalangeal syndrome type 1 and multiple exostoses type 1. Affected individuals manifest multiple dysmorphic facial features including large, laterally protruding ears, a bulbous nose, an elongated upper lip, as well as sparse scalp hair, winged scapulae, multiple cartilaginous exostoses, redundant skin, and mental retardation. A chromosomal aberration resulting in the loss of functional copies of TRPS1 and EXT1 has been found in TRPS2 patients. Defects in TRPS1 are the cause of tricho-rhino-phalangeal syndrome type 3 (TRPS3). TRPS3 is an autosomal dominant disorder characterized by craniofacial and skeletal abnormalities. It is allelic with tricho-rhino-phalangeal type 1. In TRPS3 a more severe brachydactyly and growth retardation are observed. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: C2H2-type zinc finger protein; Transcription factor
Chromosomal Location of Human Ortholog: 8q24.12
Cellular Component: nuclear chromatin; nucleoplasm; nucleus; transcription factor complex
Molecular Function: chromatin binding; protein binding; transcription factor activity
Biological Process: anatomical structure formation; cell development; cell fate commitment; gut development; heart development; negative regulation of transcription from RNA polymerase II promoter; NLS-bearing substrate import into nucleus; organ morphogenesis; regulation of chondrocyte differentiation; skeletal development; tissue development; transcription from RNA polymerase II promoter
Disease: Trichorhinophalangeal Syndrome, Type I; Trichorhinophalangeal Syndrome, Type Iii
Research Articles on TRPS1
1. Data show that co-silencing of tricho-rhino-phalangeal-syndrome (TRPS1) and cathepsin D (Cath-D) in breast cancer cells (BCC) affects the transcription of cell cycle and proliferation.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
