Full Product Name
LHX3 Antibody
Product Gene Name
anti-LHX3 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9UBR4
Other Notes
Small volumes of anti-LHX3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Western Blot (WB) of anti-LHX3 antibody
Western blot analysis LHX3 using HepG2 whole cell lysates
NCBI/Uniprot data below describe general gene information for LHX3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_055379.1
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NCBI GenBank Nucleotide #
NM_014564.4
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UniProt Primary Accession #
Q9UBR4
[Other Products]
UniProt Secondary Accession #
Q5TB39; Q5TB40; Q9NZB5; Q9P0I8; Q9P0I9[Other Products]
UniProt Related Accession #
Q9UBR4[Other Products]
Molecular Weight
43,978 Da
NCBI Official Full Name
LIM/homeobox protein Lhx3 isoform b
NCBI Official Synonym Full Names
LIM homeobox 3
NCBI Official Symbol
LHX3 [Similar Products]
NCBI Official Synonym Symbols
LIM3; CPHD3; M2-LHX3
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NCBI Protein Information
LIM/homeobox protein Lhx3
UniProt Protein Name
LIM/homeobox protein Lhx3
Protein Family
LIM/homeobox protein
UniProt Gene Name
LHX3 [Similar Products]
UniProt Synonym Gene Names
LIM homeobox protein 3 [Similar Products]
NCBI Summary for LHX3
This gene encodes a member of a large family of proteins which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor that is required for pituitary development and motor neuron specification. Mutations in this gene cause combined pituitary hormone deficiency 3. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
UniProt Comments for LHX3
Acts as a transcriptional activator. Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with POU1F1/Pit-1 (). Required for the establishment of the specialized cells of the pituitary gland and the nervous system. Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1.
Research Articles on LHX3
1. Further functional studies show that forced expression of LHX3 in lung cancer cells obviously promotes cell proliferation and invasion, whereas inhibits cell apoptosis. In summary, LHX3 is an early-stage and radiosensitivity prognostic biomarker, and a novel potential oncogene in lung adenocarcinoma .
Precautions
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Disclaimer
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