Adenosine A1 rRceptor, Polyclonal Antibody

Anti -Adenosine A1 rRceptor (ADORA1, RDC7)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 1; NC_000001.10 (203096836..203136533). Location: 1q32.1

Polyclonal

Goat

Recognizes human Adenosine A1 receptor. Species Crossreactivity: mouse, rat, canine.

Affinity Purified
Purified by affinity chromatography.

Supplied as a liquid in Tris saline, pH 7.2, 0.5% BSA, 0.02% sodium azide.

May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Small volumes of anti-ADORA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Antibodies; Abs to Receptors

ELISA (EL/EIA), Western Blot (WB)

Suitable for use in ELISA and Western Blot.
Dilution: Peptide ELISA: antibody detection limit dilution 1:64,000.
Western Blot: 0.1ug/ml. Detects bands at ~30kD and 20kD in Human Brain (Cerebellum) lysates. Optimal dilutions to be determined by the researcher.

36,512 Da[Similar Products]

adenosine A1 receptor

adenosine receptor A1; OTTHUMP00000039090; OTTHUMP00000039091

Adenosine receptor A1

AA1R_HUMAN

The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication. Transcript variants with alternative splicing in the 5' UTR have been found for this gene. [provided by RefSeq]

ADORA1: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Endoplasmic reticulum; GPCR, family 1; Apoptosis; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: endoplasmic reticulum; basolateral plasma membrane; integral to plasma membrane; postsynaptic density; dendritic spine; terminal button; axolemma; asymmetric synapse; presynaptic membrane; postsynaptic membrane; cell soma; plasma membrane; presynaptic active zone

Molecular Function: protein binding; G-protein-coupled receptor binding; protein heterodimerization activity; G-protein beta/gamma-subunit binding; adenosine receptor activity, G-protein coupled; purine nucleoside binding; phospholipase C activity; heterotrimeric G-protein binding

Biological Process: negative regulation of circadian sleep/wake cycle, non-REM sleep; relaxation of vascular smooth muscle; activation of MAPKK activity; negative regulation of glutamate secretion; negative regulation of hormone secretion; positive regulation of potassium ion transport; regulation of synaptic plasticity; positive regulation of peptide secretion; neurological control of breathing; thermoregulation; signal transduction; positive regulation of protein amino acid dephosphorylation; negative regulation of cell proliferation; regulation of glomerular filtration; cell-cell signaling; negative regulation of vasodilation; positive regulation of nucleoside transport; negative regulation of lipid catabolic process; positive regulation of epidermal growth factor receptor activity; negative regulation of blood pressure; protein targeting to membrane; negative regulation of synaptic transmission, GABAergic; inflammatory response; detection of temperature stimulus involved in sensory perception of pain; adenosine receptor signaling pathway; nervous system development; negative regulation of neurotrophin production; negative regulation of acute inflammatory response; negative regulation of synaptic transmission, glutamatergic; negative regulation of leukocyte migration; phagocytosis; response to hypoxia; regulation of sensory perception of pain; G-protein signaling, adenylate cyclase inhibiting pathway; cognition; regulation of excitatory postsynaptic membrane potential; lipid catabolic process; positive regulation of blood pressure; negative regulation of apoptosis

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