STXBP1, Polyclonal Antibody

Anti -STXBP1, CT (Syntaxin-binding Protein 1, Protein Unc-18 Homolog, Unc-18-1, Protein Unc-18 Homolog A, Unc-18A, N-Sec1, p67, UNC18A)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 9; NC_000009.11 (130374486..130454995). Location: 9q34.1

Polyclonal

Goat

Recognizes human STXBP1. Species sequence homology: mouse.

Affinity Purified
Purified by immunoaffinity chromatography.

Supplied as a liquid in Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Small volumes of anti-STXBP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Antibodies; Abs to Syntaxin, Synaptotagmin, Synaptophysin

ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)

Suitable for use in ELISA, Western Blot and Immunohistochemistry.
Dilution: ELISA: 1:16000
Western Blot: 0.1-0.3ug/ml
Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml

67,569 Da[Similar Products]

syntaxin binding protein 1

syntaxin-binding protein 1; N-Sec1; unc-18A; unc18-1; neuronal SEC1; protein unc-18 homolog 1; protein unc-18 homolog A

Syntaxin-binding protein 1

UNC18A; Unc18-1; Unc-18A  [Similar Products]

STXB1_HUMAN

This gene encodes a syntaxin-binding protein. The encoded protein appears to play a role in release of neurotransmitters via regulation of syntaxin, a transmembrane attachment protein receptor. Mutations in this gene have been associated with infantile epileptic encephalopathy-4. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010]

Function: May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions.

Subunit structure: Binds SYTL4

By similarity. Interacts with STX1A. Ref.6

Subcellular location: Cytoplasm. Membrane; Peripheral membrane protein.

Tissue specificity: Brain and spinal cord. Highly enriched in axons.

Involvement in disease: Epileptic encephalopathy, early infantile, 4 (EIEE4) [MIM:612164]: A severe form of epilepsy characterized by frequent tonic seizures or spasms beginning in infancy with a specific EEG finding of suppression-burst patterns, characterized by high-voltage bursts alternating with almost flat suppression phases. Affected individuals have neonatal or infantile onset of seizures, profound mental retardation, and MRI evidence of brain hypomyelination.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.9

Sequence similarities: Belongs to the STXBP/unc-18/SEC1 family.

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