Product Name
Rab 3 GAP p130, Polyclonal Antibody
Full Product Name
Rab 3 GAP p130 Polyclonal Antibody
Product Synonym Names
RAB3GAP1; KIAA0066; RAB3GAP; Rab3 GTPase-activating protein catalytic subunit; RAB3 GTPase-activating protein 130 kDa subunit; Rab3-GAP p130; Rab3-GAP
Product Gene Name
anti-Rab 3 GAP p130 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q15042
Specificity
Rab 3 GAP p130 Polyclonal Antibody detects endogenous levels of Rab 3 GAP p130 protein.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration
1 mg/ml (lot specific)
Immunogen Description
Synthesized peptide derived from the Internal region of human Rab 3 GAP p130.
Target Name
Rab 3 GAP p130
Preparation and Storage
Store at -20 degree C/1 year
Other Notes
Small volumes of anti-Rab 3 GAP p130 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-Rab 3 GAP p130 antibody
Total protein Ab
Applications Tested/Suitable for anti-Rab 3 GAP p130 antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-Rab 3 GAP p130 antibody
Western Blot: 1:500 - 1:2000
Immunohistochemistry: 1:100 - 1:300
ELISA: 1:40000
Not yet tested in other applications.
Western Blot (WB) of anti-Rab 3 GAP p130 antibody
Western Blot analysis of 293 cells using Rab 3 GAP p130 Polyclonal Antibody
NCBI/Uniprot data below describe general gene information for Rab 3 GAP p130. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001165906.1
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NCBI GenBank Nucleotide #
NM_001172435.1
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UniProt Primary Accession #
Q15042
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UniProt Secondary Accession #
Q659F5; Q8TBB4; A6H8Z3; C9J837[Other Products]
UniProt Related Accession #
Q15042[Other Products]
Molecular Weight
105,296 Da
NCBI Official Full Name
rab3 GTPase-activating protein catalytic subunit isoform 1
NCBI Official Synonym Full Names
RAB3 GTPase activating protein subunit 1 (catalytic)
NCBI Official Symbol
RAB3GAP1 [Similar Products]
NCBI Official Synonym Symbols
P130; WARBM1; RAB3GAP; RAB3GAP130
[Similar Products]
NCBI Protein Information
rab3 GTPase-activating protein catalytic subunit
UniProt Protein Name
Rab3 GTPase-activating protein catalytic subunit
UniProt Synonym Protein Names
RAB3 GTPase-activating protein 130 kDa subunit; Rab3-GAP p130; Rab3-GAP
UniProt Gene Name
RAB3GAP1 [Similar Products]
UniProt Synonym Gene Names
KIAA0066; RAB3GAP; Rab3-GAP [Similar Products]
UniProt Entry Name
RB3GP_HUMAN
NCBI Summary for Rab 3 GAP p130
This gene encodes the catalytic subunit of a Rab GTPase activating protein. The encoded protein forms a heterodimer with a non-catalytic subunit to specifically regulate the activity of members of the Rab3 subfamily of small G proteins. This protein mediates the hydrolysis of GTP bound Rab3 to the GDP bound form. Mutations in this gene are associated with Warburg micro syndrome. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010]
UniProt Comments for Rab 3 GAP p130
RAB3GAP1: Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters. Defects in RAB3GAP1 are the cause of Warburg micro syndrome type 1 (WARBM1). A rare syndrome characterized by microcephaly, microphthalmia, microcornia, congenital cataracts, optic atrophy, cortical dysplasia, in particular corpus callosum hypoplasia, severe mental retardation, spastic diplegia, and hypogonadism. Belongs to the Rab3-GAP catalytic subunit family. 2 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 2q21.3
Cellular Component: protein complex; cytoplasm
Molecular Function: Rab guanyl-nucleotide exchange factor activity; Rab GTPase binding
Biological Process: regulation of GTPase activity; hypothalamus development; camera-type eye development; regulation of short-term neuronal synaptic plasticity; brain development; regulation of excitatory postsynaptic membrane potential
Disease: Warburg Micro Syndrome 1
Research Articles on Rab 3 GAP p130
1. A large intragenic homozygous RAB3GAP1 microdeletion is associated with Warburg micro syndrome 1.
Precautions
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Disclaimer
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