Product Name
RAB3GAP1, Polyclonal Antibody
Full Product Name
RAB3GAP1 Antibody
Product Gene Name
anti-RAB3GAP1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q15042
Specificity
RAB3GAP1 Antibody detects endogenous levels of total RAB3GAP1 protein.
Purity/Purification
Purified from rabbit antiserum by affinity-chromatography using immunogen.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1 mg/ml (lot specific)
Target Modification
Unmodified/Total
Immunogen
The antiserum was produced against synthesized peptide derived from human RAB3GAP1.
Preparation and Storage
Stable at -20 degree C for at least 1 year.
Other Notes
Small volumes of anti-RAB3GAP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-RAB3GAP1 antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-RAB3GAP1 antibody
WB: 1:500~1:1000
IHC: 1:50~1:100
ELISA: 1:40000
Immunohistochemistry (IHC) of anti-RAB3GAP1 antibody
Immunohistochemistry analysis of paraffin-embedded human testis tissue, using RAB3GAP1 Antibody. The picture on the right is blocked with the synthesized peptide.
Western Blot (WB) of anti-RAB3GAP1 antibody
Western blot analysis of lysates from 293 cells, using RAB3GAP1 Antibody. The lane on the right is blocked with the synthesized peptide.
NCBI/Uniprot data below describe general gene information for RAB3GAP1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001165906.1
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NCBI GenBank Nucleotide #
NM_001172435.1
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UniProt Primary Accession #
Q15042
[Other Products]
UniProt Secondary Accession #
Q659F5; Q8TBB4; A6H8Z3; C9J837[Other Products]
UniProt Related Accession #
Q15042[Other Products]
NCBI Official Full Name
rab3 GTPase-activating protein catalytic subunit isoform 1
NCBI Official Synonym Full Names
RAB3 GTPase activating protein catalytic subunit 1
NCBI Official Symbol
RAB3GAP1 [Similar Products]
NCBI Official Synonym Symbols
P130; WARBM1; RAB3GAP; RAB3GAP130
[Similar Products]
NCBI Protein Information
rab3 GTPase-activating protein catalytic subunit
UniProt Protein Name
Rab3 GTPase-activating protein catalytic subunit
UniProt Synonym Protein Names
RAB3 GTPase-activating protein 130 kDa subunit; Rab3-GAP p130; Rab3-GAP
Protein Family
Rab3 GTPase-activating protein
UniProt Gene Name
RAB3GAP1 [Similar Products]
UniProt Synonym Gene Names
KIAA0066; RAB3GAP; Rab3-GAP [Similar Products]
NCBI Summary for RAB3GAP1
This gene encodes the catalytic subunit of a Rab GTPase activating protein. The encoded protein forms a heterodimer with a non-catalytic subunit to specifically regulate the activity of members of the Rab3 subfamily of small G proteins. This protein mediates the hydrolysis of GTP bound Rab3 to the GDP bound form. Mutations in this gene are associated with Warburg micro syndrome. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010]
UniProt Comments for RAB3GAP1
Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters.
Research Articles on RAB3GAP1
1. T; p. (Glu180*) and c.943C>T; p. (Arg315*).">Whole-exome sequencing, using DNA of the first fetus, was performed shortly after the birth of a male child, and two truncating RAB3GAP1 mutations were detected: c.538G>T; p. (Glu180*) and c.943C>T; p. (Arg315*).
Precautions
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Disclaimer
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