7, 8-dihydro-8-oxoguanine triphosphatase, ELISA Kit

7, 8-dihydro-8-oxoguanine triphosphatase; 8-oxo-dGTPase; Nucleoside diphosphate-linked moiety X motif 1; Nudix motif 1; NUDT1; MTH1; 3.6.1.55; 3.6.1.56; Nucleoside diphosphate-linked moiety

For Research Use Only. Not for use in diagnostic procedures.

Store at 4 degree C

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.

Small volumes of NUDT1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9428397 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the 7, 8-dihydro-8-oxoguanine triphosphatase (NUDT1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing NUDT1. The ELISA analytical biochemical technique of the MBS9428397 kit is based on NUDT1 antibody-NUDT1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect NUDT1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, NUDT1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

17,952 Da

nudix hydrolase 1

7,8-dihydro-8-oxoguanine triphosphatase

7,8-dihydro-8-oxoguanine triphosphatase

MTH1; Nudix motif 1  [Similar Products]

Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described. [provided by RefSeq, Jul 2008]

NUDT1: Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP. Belongs to the Nudix hydrolase family. 4 isoforms of the human protein are produced by alternative initiation.

Protein type: EC 3.6.1.55; EC 3.6.1.56; Hydrolase

Chromosomal Location of Human Ortholog: 7p22.3

Cellular Component: cytoplasm; cytosol; mitochondrial matrix; mitochondrion; nucleus

Molecular Function: 8-oxo-7,8-dihydroguanine triphosphatase activity; ATP diphosphatase activity; GTPase activity; m7G(5')pppN diphosphatase activity; protein binding; snoRNA binding

Biological Process: dATP catabolic process; dGTP catabolic process; DNA protection; DNA repair; purine nucleotide catabolic process; response to oxidative stress

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