Full Product Name
MYO5A Antibody, Biotin conjugated
Product Synonym Names
Unconventional myosin-Va; Dilute myosin heavy chain; non-muscle; Myosin heavy chain 12; Myosin-12; Myoxin; MYO5A; MYH12
Product Gene Name
anti-MYO5A antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9Y4I1
Purity/Purification
>95%, Protein G purified
Immunogen
Recombinant Human Unconventional myosin-Va protein (1087-1220AA)
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Preparation and Storage
Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-MYO5A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-MYO5A antibody
Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation.
Product Categories/Family for anti-MYO5A antibody
Neuroscience; Metabolism; Signal transduction
Applications Tested/Suitable for anti-MYO5A antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for MYO5A. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000250.3
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NCBI GenBank Nucleotide #
NM_000259.3
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UniProt Primary Accession #
Q9Y4I1
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UniProt Secondary Accession #
O60653; Q07902; Q16249; Q9UE30; Q9UE31; A8MZC5[Other Products]
UniProt Related Accession #
Q9Y4I1[Other Products]
Molecular Weight
218,608 Da
NCBI Official Full Name
unconventional myosin-Va isoform 1
NCBI Official Synonym Full Names
myosin VA
NCBI Official Symbol
MYO5A [Similar Products]
NCBI Official Synonym Symbols
GS1; MYO5; MYH12; MYR12
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NCBI Protein Information
unconventional myosin-Va
UniProt Protein Name
Unconventional myosin-Va
UniProt Synonym Protein Names
Dilute myosin heavy chain, non-muscle; Myosin heavy chain 12; Myosin-12; Myoxin
Protein Family
Unconventional myosin
UniProt Gene Name
MYO5A [Similar Products]
UniProt Synonym Gene Names
MYH12 [Similar Products]
NCBI Summary for MYO5A
This gene is one of three myosin V heavy-chain genes, belonging to the myosin gene superfamily. Myosin V is a class of actin-based motor proteins involved in cytoplasmic vesicle transport and anchorage, spindle-pole alignment and mRNA translocation. The protein encoded by this gene is abundant in melanocytes and nerve cells. Mutations in this gene cause Griscelli syndrome type-1 (GS1), Griscelli syndrome type-3 (GS3) and neuroectodermal melanolysosomal disease, or Elejalde disease. Multiple alternatively spliced transcript variants encoding different isoforms have been reported, but the full-length nature of some variants has not been determined. [provided by RefSeq, Dec 2008]
UniProt Comments for MYO5A
Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation.
Research Articles on MYO5A
1. Data suggest that membrane tethering mediated by endosomal RAB11A is drastically and selectively stimulated by its cognate Rab effectors, class V myosins (MYO5A and MYO5B), in a GTP-dependent manner. (RAB11A = ras-related GTPase Rab-11A; MYO5 = myosin class V)
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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