Full Product Name
HCN4 Polyclonal Antibody
Product Synonym Names
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4; HCN4
Product Gene Name
anti-HCN4 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9Y3Q4
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Immunogen
Synthesized peptide derived from human protein. at AA range: 600-680
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-HCN4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-HCN4 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-HCN4 antibody
WB: 1:500-2000
ELISA: 1:5000-20000
NCBI/Uniprot data below describe general gene information for HCN4. It may not necessarily be applicable to this product.
NCBI Accession #
NP_005468.1
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NCBI GenBank Nucleotide #
NM_005477.2
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UniProt Primary Accession #
Q9Y3Q4
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UniProt Secondary Accession #
Q9UMQ7[Other Products]
UniProt Related Accession #
Q9Y3Q4[Other Products]
NCBI Official Full Name
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
NCBI Official Synonym Full Names
hyperpolarization activated cyclic nucleotide gated potassium channel 4
NCBI Official Symbol
HCN4 [Similar Products]
NCBI Official Synonym Symbols
SSS2
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NCBI Protein Information
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
UniProt Protein Name
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Protein Family
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel
UniProt Gene Name
HCN4 [Similar Products]
NCBI Summary for HCN4
This gene encodes a member of the hyperpolarization-activated cyclic nucleotide-gated potassium channels. The encoded protein shows slow kinetics of activation and inactivation, and is necessary for the cardiac pacemaking process. This channel may also mediate responses to sour stimuli. Mutations in this gene have been linked to sick sinus syndrome 2, also known as atrial fibrillation with bradyarrhythmia or familial sinus bradycardia. Two pseudogenes have been identified on chromosome 15. [provided by RefSeq, Oct 2008]
UniProt Comments for HCN4
Hyperpolarization-activated ion channel with very slow activation and inactivation exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) that regulate the rhythm of heart beat. May contribute to the native pacemaker currents in neurons (Ih). May mediate responses to sour stimuli.
Research Articles on HCN4
1. A novel splice site HCN4 gene mutation was identified in a large family with familial bradycardia.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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