Product Name
6-phosphogluconate dehydrogenase, decarboxylating (PGD), Recombinant Protein
Full Product Name
Recombinant Sheep 6-phosphogluconate dehydrogenase, decarboxylating (PGD)
Product Gene Name
PGD recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
2-483aa, Full Length of Mature Protein
Sequence
AQADIALIGL AVMGQNLILN MNDHGFVVCA FNRTVSKVDD FLANEAKGTK VLGAHSLEEM VSKLKKPRRI ILLVKAGQAV DNFIEKLVPL LDIGDIIIDG GNSEYRDTMR RCRDLKDKGI LFVGSGVSGG EDGARYGPSL MPGGNKEAWP HIKAIFQGIA AKVGTGEPCC DWVGDDGAGH FVKMVHNGIE YGDMQLICEA YHLMKDVLGL GHKEMAKAFE EWNKTELDSF LIEITASILK FQDADGKHLL PKIRDSAGQK GTGKWTAISA LEYGVPVTLI GEAVFARCLS SLKDERIQAS KKLKGPQNIP FEGDKKSFLE DIRKALYASK IISYAQGFML LRQAATEFGW TLNYGGIALM WRGGCIIRSV FLGKIKDAFD RNPGLQNLLL DDFFKSAVEN CQDSWRRAIS TGVQAGIPMP CFTTALSFYD GYRHAMLPAN LIQAQRDYFG AHTYELLAKP GQFIHTNWTG HGGSVSSSSY NA
3D Structure
ModBase 3D Structure for P00349
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of PGD recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
PGD recombinant protein
6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentose phosphate shunt. Deficiency of this enzyme is generally asymptomatic, and the inheritance of this disorder is autosomal dominant. Hemolysis results from combined deficiency of 6-phosphogluconate dehydrogenase and 6-phosphogluconolactonase suggesting a synergism of the two enzymopathies.
NCBI/Uniprot data below describe general gene information for PGD. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001009467.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001009467.2
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UniProt Primary Accession #
P00349
[Other Products]
UniProt Related Accession #
P00349[Other Products]
Molecular Weight
52,970 Da
NCBI Official Full Name
6-phosphogluconate dehydrogenase, decarboxylating
NCBI Official Symbol
PGD [Similar Products]
NCBI Official Synonym Symbols
6-PGDH
[Similar Products]
NCBI Protein Information
6-phosphogluconate dehydrogenase, decarboxylating
UniProt Protein Name
6-phosphogluconate dehydrogenase, decarboxylating
UniProt Gene Name
PGD [Similar Products]
UniProt Comments for PGD
Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.
Research Articles on PGD
1. Methionine at position 13 plays a significant role in orienting the cofactor nicotinamide ring with respect to geometry and distance, thereby optimizing the geometry for hydride transfer, and perhaps the decarboxylation step in the 6PGDH reaction.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
