CD158f1/2, Polyclonal Antibody

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

The antibody detects endogenous CD158f1/2

Affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.

1 mg/ml (lot specific)

Store at -20 degree C

Small volumes of anti-CD158f1/2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Total protein Ab

Immunohistochemistry (IHC)

IHC: 1:50-300

Immunohistochemical analysis of paraffin-embedded human-kidney, antibody was diluted at 1:200

40,678 Da

killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5A

killer cell immunoglobulin-like receptor 2DL5A

Killer cell immunoglobulin-like receptor 2DL5A

CD158F; CD158F1; KIR2DL5  [Similar Products]

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]

KIR2DL5A: Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis. Belongs to the immunoglobulin superfamily.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 19p13.3

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