AQP4, Polyclonal Antibody

MIWC; WCH4

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Affinity Purification

Store at -20 degree C. Avoid freeze / thaw cycles.

Small volumes of anti-AQP4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. This protein is the predominant aquaporin found in brain and has an important role in brain water homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon.

Polyclonal Antibodies

Western Blot (WB), Immunohistochemistry (IHC)

WB: 1:500 - 1:2000
IHC: 1:50 - 1:200

Immunohistochemistry of paraffin-embedded rat kidney using AQP4 antibody at dilution of 1:50 (40x lens).

Immunohistochemistry of paraffin-embedded mouse lung using AQP4 antibody at dilution of 1:50 (40x lens).

Immunohistochemistry of paraffin-embedded mouse kidney using AQP4 antibody at dilution of 1:50 (40x lens).

32kDa/34kDa

aquaporin 4

aquaporin-4

Aquaporin-4

AQP-4; MIWC  [Similar Products]

This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. This protein is the predominant aquaporin found in brain and has an important role in brain water homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]

Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system.

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