P2RY12/P2Y12, Polyclonal Antibody

Rabbit Polyclonal to Human P2RY12/P2Y12; P2RY12; ADP-glucose receptor; ADPG-R; p2Y(12)R; p2Y(ADP); p2T(AC); p2Y12; Platelet ADP receptor; SP1999; p2RY12; p2Y purinoceptor 12; Purinergic receptor P2RY12; BDPLT8; Gi-coupled ADP receptor HORK3; HORK3; p2Y(AC); p2Y(cyc); p2Y12 platelet ADP receptor

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Human P2RY12/P2Y12

Affinity Purified

PBS, pH 7.4, 0.05% sodium azide.

Store at 4 degree C for up to 1 year.
Avoid repeated freezing and thawing.

Small volumes of anti-P2RY12/P2Y12 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

P2RY12/P2Y12 belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacologicalselectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelet aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Mutations in this gene are implicated inbleeding disorder, platelet type 8 (BDPLT8).

GPCR; Purinergic

Immunohistochemistry (IHC) Paraffin, Western Blot (WB)

IHC-P: 1:100
WB: 1:500-1:2000

Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)

Human Brain, Cortex, White Matter: Formalin-Fixed, Paraffin-Embedded (FFPE)

39,439 Da

purinergic receptor P2Y12

P2Y purinoceptor 12

P2Y purinoceptor 12

HORK3; P2Y12; ADPG-R; P2Y(ADP)  [Similar Products]

The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelet aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Mutations in this gene are implicated in bleeding disorder, platelet type 8 (BDPLT8). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Required for normal platelet aggregation and blood coagulation.

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