CD4, Polyclonal Antibody

CD 4; CD4 (L3T4); CD4 antigen (p55); CD4 antigen; CD4 molecule; CD4 receptor; CD4+ Lymphocyte deficiency, included; CD4mut; L3T4; Leu3; Ly-4; Lymphocyte antigen CD4; p55; T cell differentiation antigen L3T4; T cell OKT4 deficiency, included; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4; W3/25 antigen antibody

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

BIOTIN-Conjugated

0.55-0.75 ug/ul in antibody stabilization buffer (lot specific)

-20 degree C for long term storage

Small volumes of anti-CD4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

BIOTIN-Conjugated T-cell surface glycoprotein CD4 isoform 1 Antibody C-epitope
Accesory protein for MHC class-II antigen/T-cell receptor interaction.

ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB)

Dot Blot: 1:10,000
ELISA: 1:10,000
Immunoprecipitation: 1:150
Western Blot: 1:500

51,111 Da

CD4 molecule

T-cell surface glycoprotein CD4

T-cell surface glycoprotein CD4

CD4_HUMAN

This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010]

CD4: Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts. Associates with LCK. Binds to HIV-1 gp120 and to P4HB/PDI and upon HIV-1 binding to the cell membrane, is part of P4HB/PDI- CD4-CXCR4-gp120 complex. Interacts with HIV-1 Envelope polyprotein gp160 and protein Vpu. Interacts with Human Herpes virus 7 capsid proteins. Interacts with PTK2/FAK1; this interaction requires the presence of HIV-1 gp120.

Protein type: Membrane protein, integral; Cell surface

Chromosomal Location of Human Ortholog: 12p13.31

Cellular Component: early endosome; endoplasmic reticulum lumen; endoplasmic reticulum membrane; external side of plasma membrane; integral to membrane; lipid raft; plasma membrane; T cell receptor complex

Molecular Function: coreceptor activity; enzyme binding; extracellular matrix structural constituent; glycoprotein binding; immunoglobulin binding; MHC class II protein binding; protein binding; protein homodimerization activity; protein kinase binding; receptor activity; transmembrane receptor activity; viral receptor activity; zinc ion binding

Biological Process: adaptive immune response; cell surface receptor linked signal transduction; cytokine production; defense response to Gram-negative bacterium; entry into host cell; enzyme linked receptor protein signaling pathway; immune response; induction by virus of cell-cell fusion in host; maintenance of cellular protein localization; positive regulation of calcium-mediated signaling; positive regulation of interleukin-2 biosynthetic process; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein kinase activity; positive regulation of T cell proliferation; regulation of defense response to virus by virus; regulation of T cell activation; response to estradiol stimulus; response to vitamin D; signal transduction; T cell costimulation; T cell differentiation; T cell receptor signaling pathway; T cell selection; transmembrane receptor protein tyrosine kinase signaling pathway; viral envelope fusion with host membrane

Disease: Okt4 Epitope Deficiency

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