Full Product Name
CAC1S Polyclonal Antibody
Product Synonym Names
Voltage-dependent L-type calcium channel subunit alpha-1S; Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle; Voltage-gated calcium channel subunit alpha Cav1.1; CACNA1S; CACH1; CACN1; CACNL1A3
Product Gene Name
anti-CAC1S antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q13698
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Immunogen
Synthesized peptide derived from human protein. at AA range: 330-410
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-CAC1S antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CAC1S antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-CAC1S antibody
WB: 1:500-2000
ELISA: 1:5000-20000
NCBI/Uniprot data below describe general gene information for CAC1S. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000060.2
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NCBI GenBank Nucleotide #
NM_000069.2
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UniProt Primary Accession #
Q13698
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UniProt Secondary Accession #
Q12896; Q13934; A4IF51; B1ALM2[Other Products]
UniProt Related Accession #
Q13698[Other Products]
NCBI Official Full Name
voltage-dependent L-type calcium channel subunit alpha-1S
NCBI Official Synonym Full Names
calcium voltage-gated channel subunit alpha1 S
NCBI Official Symbol
CACNA1S [Similar Products]
NCBI Official Synonym Symbols
MHS5; HOKPP; TTPP1; Cav1.1; HOKPP1; hypoPP; CCHL1A3; CACNL1A3
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NCBI Protein Information
voltage-dependent L-type calcium channel subunit alpha-1S
UniProt Protein Name
Voltage-dependent L-type calcium channel subunit alpha-1S
UniProt Synonym Protein Names
Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle; Voltage-gated calcium channel subunit alpha Cav1.1
UniProt Gene Name
CACNA1S [Similar Products]
UniProt Synonym Gene Names
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NCBI Summary for CAC1S
This gene encodes one of the five subunits of the slowly inactivating L-type voltage-dependent calcium channel in skeletal muscle cells. Mutations in this gene have been associated with hypokalemic periodic paralysis, thyrotoxic periodic paralysis and malignant hyperthermia susceptibility. [provided by RefSeq, Jul 2008]
UniProt Comments for CAC1S
Pore-forming, alpha-1S subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle via their interaction with RYR1, which triggers Ca2+ release from the sarcplasmic reticulum and ultimately results in muscle contraction. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group.
Research Articles on CAC1S
1. review of the pharmacogenetics and pathophysiology of CACNA1S mutations in malignant hyperthermia susceptibility type 5 (MHS5); several mutations are known to be risk factors for increased susceptibility; at present, one or at most six CACNA1S mutations display significant linkage or association either to clinically diagnosed MH or to MHS
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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