Full Product Name
ARHGAP22 Antibody
Product Gene Name
anti-ARHGAP22 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q7Z5H3
Other Notes
Small volumes of anti-ARHGAP22 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Western Blot (WB) of anti-ARHGAP22 antibody
Western blot analysis ARHGAP22 using K562 whole cell lysates
NCBI/Uniprot data below describe general gene information for ARHGAP22. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001242953.1
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NCBI GenBank Nucleotide #
NM_001256024.1
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UniProt Primary Accession #
Q7Z5H3
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UniProt Secondary Accession #
O00152; Q6ZSB0; A0AVP7; A5YM75; B4DED8; B9EGA0; C9JDM2[Other Products]
UniProt Related Accession #
Q7Z5H3[Other Products]
Molecular Weight
77,457 Da
NCBI Official Full Name
rho GTPase-activating protein 22 isoform 1
NCBI Official Synonym Full Names
Rho GTPase activating protein 22
NCBI Official Symbol
ARHGAP22 [Similar Products]
NCBI Official Synonym Symbols
RhoGAP2; RhoGap22
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NCBI Protein Information
rho GTPase-activating protein 22
UniProt Protein Name
Rho GTPase-activating protein 22
UniProt Synonym Protein Names
Rho-type GTPase-activating protein 22
Protein Family
Rho GTPase-activating protein
UniProt Gene Name
ARHGAP22 [Similar Products]
UniProt Synonym Gene Names
RHOGAP2 [Similar Products]
NCBI Summary for ARHGAP22
This gene encodes a member of the GTPase activating protein family which activates a GTPase belonging to the RAS superfamily of small GTP-binding proteins. The encoded protein is insulin-responsive, is dependent on the kinase Akt and requires the Akt-dependent 14-3-3 binding protein which binds sequentially to two serine residues. The result of these interactions is regulation of cell motility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
UniProt Comments for ARHGAP22
Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter ().
Research Articles on ARHGAP22
1. There is a significant association between single nucleotide polymorphism in the ARHGAP22 gene and diabetic retinopathy risk in a Han Chinese population
Precautions
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Disclaimer
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