Product Name
AKTIP, cDNA Clone
Full Product Name
AKTIP cDNA Clone
Product Gene Name
AKTIP cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgaaccctt tctggagcat gtctacaagc tctgtacgca aacgatctga aggtgaagag aagacattaa caggggacgt gaaaaccagt cctccacgaa ctgcaccaaa gaaacagctg ccttctattc ccaaaaatgc tttgcccata actaagccta catctcctgc cccagcagca cagtcaacaa atggcacgca tgcgtcctat ggacccttct acctggaata ctctcttctt gcagaattta ccttggttgt gaagcagaag ctaccaggcg tctatgtgca gccatcttat cgctctgcat taatgtggtt tggagtaata ttcatacggc atggacttta ccaagatggc gtatttaagt ttacagttta catccctgat aactatccag atggtgactg tccacgcttg gtgttcgata ttcctgtctt tcacccgcta gttgatccca cctcaggtga gctggatgtg aagagagcat ttgcaaaatg gaggcggaac cataatcata tttggcaggt attaatgtat gcaaggagag ttttctacaa gattgataca gcaagccccc tgaacccaga ggctgcagta ctgtatgaaa aagatattca gctttttaaa agtaaagttg ttgacagtgt taaggtgtgc actgctcgtt tgtttgacca acctaaaata gaagacccct atgcaattag cttttctcca tggaatcctt ctgtacatga tgaagccaga gaaaagatgc tgactcagaa aaagcctgaa gaacagcaca ataaaagtgt tcatgttgct ggcctgtcat gggtaaagcc tggctcagta cagcctttca gtaaagaaga gaaaacagtg gcgacttaa
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of AKTIP cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for AKTIP. It may not necessarily be applicable to this product.
NCBI Accession #
BC001134
[Other Products]
UniProt Secondary Accession #
Q503B1; Q53H38[Other Products]
UniProt Related Accession #
Q9H8T0[Other Products]
Molecular Weight
33,256 Da
NCBI Official Full Name
Homo sapiens AKT interacting protein, mRNA
NCBI Official Synonym Full Names
AKT interacting protein
NCBI Official Symbol
AKTIP [Similar Products]
NCBI Official Synonym Symbols
FT1; FTS
[Similar Products]
NCBI Protein Information
AKT-interacting protein
UniProt Protein Name
AKT-interacting protein
UniProt Synonym Protein Names
Ft1; Fused toes protein homolog
Protein Family
AKT-interacting protein
UniProt Gene Name
AKTIP [Similar Products]
UniProt Synonym Gene Names
FTS [Similar Products]
UniProt Entry Name
AKTIP_HUMAN
NCBI Summary for AKTIP
The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
UniProt Comments for AKTIP
AKTIP: an oncogenic membrane-associated protein that is a component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade. Belongs to the ubiquitin-conjugating enzyme family. FTS subfamily. Component of the FTS/Hook/FHIP complex (FHF complex), composed of AKTIP/FTS, FAM160A2, and one or more members of the Hook family of proteins HOOK1, HOOK2, and HOOK3. May interact directly with HOOK1, HOOK2 and HOOK3. The FHF complex associates with the homotypic vesicular sorting complex (the HOPS complex). Apparently interacts with AKT1. A member of the ubiquitin-conjugating enzyme family, FTS subfamily. Lacks the conserved Cys residue necessary for ubiquitin-conjugating enzyme E2 activity. Two isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, peripheral; Vesicle; Apoptosis
Chromosomal Location of Human Ortholog: 16q12.2
Cellular Component: cytoplasm; Golgi apparatus; nucleolus; plasma membrane
Molecular Function: protein binding; ubiquitin protein ligase binding
Biological Process: early endosome to late endosome transport; endosome organization and biogenesis; endosome to lysosome transport; lysosome organization and biogenesis; positive regulation of protein amino acid phosphorylation; positive regulation of protein binding
Research Articles on AKTIP
1. AKTIP interacts with telomeric DNA and is required for telomere maintenance.
Precautions
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Disclaimer
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