Aldo-Keto Reductase Family 1 Member C1, Monoclonal Antibody

AKR1C1 Antibody; Aldo-Keto Reductase Family 1 Member C1, Mouse Anti Human; DDH1; DDH; HAKRC; 20-alpha-HSD; DD1/DD2; HBAB; C9; DD1; H-37; MBAB; MGC8954; 2-ALPHA-HSD; AKR1C1; Aldo-keto reductase family 1 member C1; 20-alpha-hydroxysteroid dehydrogenase; Trans-1; 2-dihydrobenzene-1; 2-diol dehydrogenase; Indanol dehydrogenase; Dihydrodiol dehydrogenase 1/2; Chlordecone reductase homolog HAKRC; High-affinity hepatic bile acid-binding protein

For Research Use Only. Not for use in diagnostic procedures.

Monoclonal

IgG1 heavy chain and k light chain

PAT6D10AT

Mouse

AKR1C1 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.

1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide.

For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles.
12 months at -20 degree C. 1 month at 4 degree C.

Small volumes of anti-AKR1C1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Introduction: AKR1C1 transfers progesterone to its inactive state or in other words catalyzes the reaction of 20-alpha-hydroxy progesterone (20-alpha-OHP). In the liver and intestine. AKR1C1 transfers bile and monitors the intrahepatic bile acid concentration though it has a low bile-binding ability. AKR1C1 participates in myelin formation. AKR1C1 is part of the aldo/keto reductase superfamily, which has over 40 known enzymes which catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors thus display overlapping but distinct substrate specificity.

MONOCLONAL/POLYCLONAL ANTIBODIES, MISCELLANEOUS ANTIBODIES; Monoclonal Antibodies; Anti Human Enzyme

ELISA (EIA), Western Blot (WB)

AKR1C1 antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:1000. Recommended starting dilution is 1:1000.

36,788 Da

aldo-keto reductase family 1, member C1

aldo-keto reductase family 1 member C1; 20 alpha-hydroxysteroid dehydrogenase; 20-alpha-hydroxysteroid dehydrogenase; aldo-keto reductase C; chlordecone reductase homolog HAKRC; dihydrodiol dehydrogenase 1; dihydrodiol dehydrogenase 1/2; dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase; dihydrodiol dehydrogenase isoform DD1; hepatic dihydrodiol dehydrogenase; high-affinity hepatic bile acid-binding protein; indanol dehydrogenase; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; type II 3-alpha-hydroxysteroid dehydrogenase

Aldo-keto reductase family 1 member C1

DDH; DDH1; 20-alpha-HSD; DD1/DD2; HBAB  [Similar Products]

AK1C1_HUMAN

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq, Jul 2008]

AKR1C1: Converts progesterone to its inactive form, 20-alpha- dihydroxyprogesterone (20-alpha-OHP). In the liver and intestine, may have a role in the transport of bile. May have a role in monitoring the intrahepatic bile acid concentration. Has a low bile-binding ability. May play a role in myelin formation. Belongs to the aldo/keto reductase family.

Protein type: EC 1.3.1.20; EC 1.1.1.149; Xenobiotic Metabolism - metabolism by cytochrome P450; Oxidoreductase; EC 1.1.1.112

Chromosomal Location of Human Ortholog: 10p15-p14

Cellular Component: cytosol

Molecular Function: oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor; ketosteroid monooxygenase activity; 3-alpha-hydroxysteroid dehydrogenase (B-specific) activity; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity; carboxylic acid binding; bile acid binding; aldo-keto reductase activity; 20-alpha-hydroxysteroid dehydrogenase activity; indanol dehydrogenase activity; aldehyde reductase activity; phenanthrene 9,10-monooxygenase activity

Biological Process: bile acid and bile salt transport; phototransduction, visible light; cholesterol homeostasis; response to organophosphorus; retinal metabolic process; epithelial cell differentiation; bile acid metabolic process; xenobiotic metabolic process; cholesterol absorption; digestion; progesterone metabolic process; retinoid metabolic process; protein homooligomerization

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