Product Name
AKR1D1, Polyclonal Antibody
Full Product Name
AKR1D1 Antibody
Product Gene Name
anti-AKR1D1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human
Predicted: Mouse, Rat
Form/Format
Purified by protein affinity column containing 1% BSA and 0.02% NaN3
Preparation and Storage
Already reconstituted in 200ul sterile H2O. The antibody is stable for at least one year when stored at-20 degree C after reconstitution. Avoid repeated freeze/defrost cycles.
Other Notes
Small volumes of anti-AKR1D1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-AKR1D1 antibody
Rabbit polyclonal AKR1D1 (1) antibody was raised against a recombinate human AKR1D1 protein 73-315aa (BC130625).
Product Categories/Family for anti-AKR1D1 antibody
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
Applications Tested/Suitable for anti-AKR1D1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-AKR1D1 antibody
ELISA: 1:20,000-1:80,000
WB: 1:1,000-1:2,000
IHC: 1:100-1:500
Testing Data of anti-AKR1D1 antibody
Testing Data of anti-AKR1D1 antibody
NCBI/Uniprot data below describe general gene information for AKR1D1. It may not necessarily be applicable to this product.
NCBI Accession #
BC130625
[Other Products]
UniProt Secondary Accession #
A1L4P6; A8K060; B4DPN3; B4DPN8[Other Products]
UniProt Related Accession #
P51857[Other Products]
Molecular Weight
32,890 Da
NCBI Official Full Name
Homo sapiens aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase), mRNA
NCBI Official Synonym Full Names
aldo-keto reductase family 1 member D1
NCBI Official Symbol
AKR1D1 [Similar Products]
NCBI Official Synonym Symbols
CBAS2; SRD5B1; 3o5bred
[Similar Products]
NCBI Protein Information
3-oxo-5-beta-steroid 4-dehydrogenase
UniProt Protein Name
3-oxo-5-beta-steroid 4-dehydrogenase
UniProt Synonym Protein Names
Aldo-keto reductase family 1 member D1; Delta(4)-3-ketosteroid 5-beta-reductase; Delta(4)-3-oxosteroid 5-beta-reductase
Protein Family
3-oxo-5-beta-steroid 4-dehydrogenase
UniProt Gene Name
AKR1D1 [Similar Products]
UniProt Synonym Gene Names
SRD5B1 [Similar Products]
NCBI Summary for AKR1D1
The enzyme encoded by this gene is responsible for the catalysis of the 5-beta-reduction of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure. Deficiency of this enzyme may contribute to hepatic dysfunction. Three transcript variants encoding different isoforms have been found for this gene. Other variants may be present, but their full-length natures have not been determined yet. [provided by RefSeq, Jul 2010]
UniProt Comments for AKR1D1
Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4-cholesten-3-one can also act as substrates.
Product References and Citations for anti-AKR1D1 antibody
(1) Steen, N.E., Tesli, M., Kahler, A.K., et al. SRD5A2 is associated with increased cortisol metabolism in schizophrenia spectrum disorders. Prog. Neuropsychopharmacol. Biol. Psychiatry 34 (8), 1500-1506 (2010).
Research Articles on AKR1D1
1. T(p.Q285X), two novel mutations originated from his mother and father, respectively">infant proved to be a compound heterozygote of the AKR1D1 variants c.579+2delT and c.853C>T(p.Q285X), two novel mutations originated from his mother and father, respectively
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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