BAAT, Polyclonal Antibody

BACAT; BAT; FLJ20300; MGC104432

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Antigen affinity purification

Store at -20 degree C. Avoid freeze / thaw cycles

Manufactured in an ISO 9001:2015 Certified Laboratory.

Small volumes of anti-BAAT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

ELISA (EIA), Western Blot (WB)

WB: 1:200-1:2000

46,299 Da

bile acid CoA:amino acid N-acyltransferase

bile acid-CoA:amino acid N-acyltransferase; bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase); bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase); long-chain fatty-acyl-CoA hydrolase

Bile acid-CoA:amino acid N-acyltransferase

BACAT; BAT  [Similar Products]

BAAT_HUMAN

The protein encoded by this gene is a liver enzyme that catalyzes the transfer of C24 bile acids from the acyl-CoA thioester to either glycine or taurine, the second step in the formation of bile acid-amino acid conjugates. The bile acid conjugates then act as a detergent in the gastrointestinal tract, which enhances lipid and fat-soluble vitamin absorption. Defects in this gene are a cause of familial hypercholanemia (FHCA). Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

BAAT: Involved in bile acid metabolism. In liver hepatocytes catalyzes the second step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi. The major components of bile are cholic acid and chenodeoxycholic acid. In a first step the bile acids are converted to an acyl-CoA thioester, either in peroxisomes (primary bile acids deriving from the cholesterol pathway), or cytoplasmic at the endoplasmic reticulum (secondary bile acids). May catalyze the conjugation of primary or secondary bile acids, or both. The conjugation increases the detergent properties of bile acids in the intestine, which facilitates lipid and fat-soluble vitamin absorption. In turn, bile acids are deconjugated by bacteria in the intestine and are recycled back to the liver for reconjugation (secondary bile acids). May also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids. In vitro, catalyzes the hydrolysis of long- and very long-chain saturated acyl-CoAs to the free fatty acid and coenzyme A (CoASH), and conjugates glycine to these acyl-CoAs. Defects in BAAT are involved in familial hypercholanemia (FHCA). FHCA is a disorder characterized by elevated serum bile acid concentrations, itching, and fat malabsorption. Belongs to the C/M/P thioester hydrolase family.

Protein type: EC 2.3.1.65; Lipid Metabolism - unsaturated fatty acid biosynthesis; Transferase; Other Amino Acids Metabolism - taurine and hypotaurine; EC 3.1.2.2; Hydrolase; Lipid Metabolism - primary bile acid biosynthesis

Chromosomal Location of Human Ortholog: 9q22.3

Cellular Component: peroxisomal matrix; peroxisome; cytosol

Molecular Function: N-acyltransferase activity; glycine N-choloyltransferase activity; palmitoyl-CoA hydrolase activity; receptor binding

Biological Process: bile acid and bile salt transport; glycine metabolic process; bile acid biosynthetic process; organ regeneration; acyl-CoA metabolic process; bile acid metabolic process; liver development; fatty acid metabolic process; taurine metabolic process

Disease: Hypercholanemia, Familial

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