Neurogranin, NRGN, Polyclonal Antibody

Anti -Neurogranin, NRGN (Protein Kinase C Substrate, RC3)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 11; NC_000011.9 (124609829..124617102). Location: 11q24

Polyclonal

IgG

Goat

Recognizes human Neurogranin. Species crossreactivity

Affinity Purified
Purified by peptide affinity chromatography.

Supplied as a liquid in Tris saline, pH 7.2, 0.5% BSA, 0.02% sodium azide.

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Small volumes of anti-NRGN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated sequences. It is suggested that the NRGN is a direct target for thyroid hormone in human brain, and that control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in ***** subjects.

Antibodies; Abs to Protein Kinase Substrates

ELISA (EL/EIA), Western Blot (WB)

Suitable for use in ELISA and Western Blot.
Dilution: Peptide ELISA Titer: 1:8000
Western Blot: 0.1-0.3ug/ml detects ~15kD band observed in Human Brain (Cerebral Cortex and Hippocampus), and in Mouse Brain and Rat Brain lysates (calculated MW of 7.6kD according to NP_006167.1). There is also an additional 16kD band. The observed molecular weights correspond to earlier findings in literature with different antibodies (Li et al, J Biol Chem. 1999 Jan 15;274(3):1294-300;

7,618 Da[Similar Products]

neurogranin (protein kinase C substrate, RC3)

neurogranin; ng; OTTHUMP00000231529; calmodulin-binding protein; protein kinase C substrate

Neurogranin

NEUG_HUMAN

Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated sequences. It is suggested that the NRGN is a direct target for thyroid hormone in human brain, and that control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in ***** subjects. [provided by RefSeq]

neurogranin: Acts as a third messenger substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium. Belongs to the neurogranin family.

Protein type: Cell development/differentiation

Chromosomal Location of Human Ortholog: 11q24

Cellular Component: intracellular

Molecular Function: calmodulin binding

Biological Process: nervous system development; signal transduction

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