Full Product Name
FBLN1 Antibody
Product Synonym Names
FBLN
Product Gene Name
anti-FBLN1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen affinity purification
Immunogen
Fusion protein of FBLN1
Calculated Molecular Weight: 703aa; 77kd
Observed Molecular Weight: 72-74kd
Buffer
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-8675 / sc-8674 / sc-20818
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-FBLN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-FBLN1 antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-FBLN1 antibody
WB: 1:500-1:5000
Testing Data of anti-FBLN1 antibody
NCBI/Uniprot data below describe general gene information for FBLN1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_006478.2
[Other Products]
NCBI GenBank Nucleotide #
NM_006487.2
[Other Products]
UniProt Secondary Accession #
P23143; P23144; P37888; Q5TIC4; Q8TBH8; Q9HBQ5; Q9UC21; Q9UGR4; Q9UH41; B0QY42; B1AHL4[Other Products]
UniProt Related Accession #
P23142[Other Products]
Molecular Weight
74,434 Da
NCBI Official Full Name
fibulin-1 isoform A
NCBI Official Synonym Full Names
fibulin 1
NCBI Official Symbol
FBLN1 [Similar Products]
NCBI Official Synonym Symbols
FBLN; FIBL1
[Similar Products]
NCBI Protein Information
fibulin-1
UniProt Protein Name
Fibulin-1
UniProt Gene Name
FBLN1 [Similar Products]
UniProt Synonym Gene Names
FIBL-1 [Similar Products]
UniProt Entry Name
FBLN1_HUMAN
NCBI Summary for FBLN1
Fibulin 1 is a secreted glycoprotein that becomes incorporated into a fibrillar extracellular matrix. Calcium-binding is apparently required to mediate its binding to laminin and nidogen. It mediates platelet adhesion via binding fibrinogen. Four splice variants which differ in the 3' end have been identified. Each variant encodes a different isoform, but no functional distinctions have been identified among the four variants. [provided by RefSeq, Jul 2008]
UniProt Comments for FBLN1
FBLN1: Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. Has been implicated in a role in cellular transformation and tumor invasion, it appears to be a tumor suppressor. May play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots. Could play a significant role in modulating the neurotrophic activities of APP, particularly soluble APP. A chromosomal aberration involving FBLN1 is found in a complex type of synpolydactyly referred to as 3/3-prime/4 synpolydactyly associated with metacarpal and metatarsal synostoses. Reciprocal translocation t(12;22)(p11.2;q13.3) with C12orf2. Fibroblasts derived from a patient with synpolydactyly displayed alterations in the level of isoform D splice variant incorporated into the ECM and secreted into the conditioned culture medium. By contrast, the expression of isoform C was not perturbed in the patients fibroblasts. Furthermore, no aberrant polypeptides were detected in extracts of cultured patients fibroblasts. The translocation t(12;22) may result in haploinsufficiency of the isoform D splice variant, which could lead to the observed limb malformation. Elevated expression and altered processing of FBLN1 protein is associated with human breast cancer. Belongs to the fibulin family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Extracellular matrix; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 22q13.31
Cellular Component: extracellular matrix; proteinaceous extracellular matrix; extracellular space; extracellular region; basement membrane
Molecular Function: protease activator activity; extracellular matrix structural constituent; calcium ion binding
Biological Process: extracellular matrix organization and biogenesis; viral reproduction; embryo implantation
Disease: Synpolydactyly 2
Research Articles on FBLN1
1. Mutation of fibulin-1 causes a novel syndrome involving the central nervous system and connective tissues.
Precautions
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Disclaimer
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