Product Name
OXSR1, cDNA Clone
Full Product Name
OXSR1 cDNA Clone
Product Gene Name
OXSR1 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgtccgagg actcgagcgc cctgccctgg tccatcaaca gggacgatta cgagctgcag gaggtgatcg ggagtggagc aactgctgta gtccaagcag cttattgtgc ccctaaaaag gagaaagtgg caatcaaacg gataaacctt gagaaatgtc aaactagcat ggatgaactc ctgaaagaaa ttcaagccat gagtcaatgc catcatccta atattgtatc ttactacaca tcttttgtgg taaaagatga gctgtggctt gtcatgaagc tgctaagtgg aggttctgtt ctggatatta ttaagcacat tgtggcaaaa ggggaacaca aaagtggagt cctagatgaa tctaccattg ctacgatact ccgagaagta ctggaagggc tggaatatct gcataaaaat ggacagatcc acagagatgt gaaagctgga aacattcttc ttggagaaga tggctcagta cagattgcag actttggggt tagtgctttt ttagcaactg gtggtgatat tacccgaaat aaagtgagaa agacctttgt tggcacccct tgttggatgg cacctgaagt tatggaacag gtccgtggtt atgatttcaa agctgatatt tggagttttg gaattacagc aattgaattg gctacagggg cggctcctta tcataaatat ccaccaatga aggttttaat gctgacactg cagaacgatc ctccttcttt ggaaactggt gttcaagata aagaaatgct gaaaaaatat ggaaaatcat ttagaaaaat gatttcattg tgccttcaaa aagatccaga aaaaagacca acagcagcag aactattaag gcacaaattt ttccagaaag caaagaataa agaatttctt caagaaaaaa cattgcagag agcaccaacc atttctgaaa gagcaaaaaa ggttcggaga gtaccaggtt ccagtgggcg tcttcataag acagaggatg gaggctggga gtggagtgat gatgaatttg atgaagaaag tgaggaaggg aaagcagcaa tttcacaact caggtctccc cgagtgaaag aatcaatatc aaattctgag ctctttccaa caactgatcc tgtgggtact ttgctccaag ttccagaaca gatctctgct catctacctc agccagctgg gcagattgct acacagccaa ctcaagtctc tctcccaccc accgcagagc cagcaaaaac agctcaggct ttgtcttcag gatcaggttc acaagaaacc aagatcccaa tcagtctagt actaagatta aggaattcca aaaaagaact aaatgatatt cgatttgaat ttactcctgg gagagataca gcagagggtg tctctcagga actcatttct gctggcctgg tcgacggaag ggatttagta atagtggcag ctaatttgca gaaaattgtg gaagaacctc agtcaaatcg atctgtcact ttcaaactgg catctggtgt cgaaggctca gatattcctg atgatggtaa actgatagga tttgcccagc tcagcatcag ctaa
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of OXSR1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for OXSR1. It may not necessarily be applicable to this product.
NCBI Accession #
BC008726
[Other Products]
UniProt Secondary Accession #
Q3LR53; Q7Z501; Q9UPQ1[Other Products]
UniProt Related Accession #
O95747[Other Products]
Molecular Weight
58,022 Da
NCBI Official Full Name
Homo sapiens oxidative-stress responsive 1, mRNA
NCBI Official Synonym Full Names
oxidative stress responsive 1
NCBI Official Symbol
OXSR1 [Similar Products]
NCBI Official Synonym Symbols
OSR1
[Similar Products]
NCBI Protein Information
serine/threonine-protein kinase OSR1
UniProt Protein Name
Serine/threonine-protein kinase OSR1
UniProt Synonym Protein Names
Oxidative stress-responsive 1 protein
Protein Family
Serine/threonine-protein kinase
UniProt Gene Name
OXSR1 [Similar Products]
UniProt Entry Name
OXSR1_HUMAN
NCBI Summary for OXSR1
The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton. [provided by RefSeq, Jul 2008]
UniProt Comments for OXSR1
OSR1: oxidative-stress responsive 1 protein is a ubiquitously expressed protein kinase of the STE20 family. Regulates Na-K-Cl cotransporter (NKCC) activity. Regulates downstream kinases in response to environmental stress. May also have a function in regulating the actin cytoskeleton. Binds to and phosphorylates PAK1. Interacts and is phosphorylated by WNK1. Knockdown of either WNK1 or OXSR1 reduces NKCC activity. Interacts with chloride channel proteins SLC12A6 isoform 2, SLC12A1 and SLC12A2 but not with SLC12A4 and SLC12A7, possibly establishing sensor/signaling modules that initiate the cellular response to environmental stress. An important paralog of this gene is STRADB.
Protein type: Protein kinase, STE; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; STE group; STE20 family; FRAY subfamily
Chromosomal Location of Human Ortholog: 3p22.2
Cellular Component: cytoplasm
Molecular Function: ATP binding; magnesium ion binding; protein binding; protein serine/threonine kinase activity; receptor signaling protein serine/threonine kinase activity
Biological Process: peptidyl-threonine phosphorylation; protein amino acid phosphorylation
Research Articles on OXSR1
1. the WNK-regulated SPAK/OSR1 kinases directly phosphorylate the N[K]CCs and KCCs, promoting their stimulation and inhibition respectively.
Precautions
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Disclaimer
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