Product Name
DCTN1, cDNA Clone
Full Product Name
DCTN1 cDNA Clone
Product Gene Name
DCTN1 cdna clone
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgatgagac aggcaccgac agcccgaaag accacaactc ggcgacccaa gcccacgcgc ccagccagta ctggggtggc tggggccagt agctccctgg gcccctctgg ctcagcgtca gcaggtgagc tgagcagcag tgagcccagc accccggctc agactccgct ggcagcaccc atcatcccca cgccggtcct cacctctcct ggagcagtcc ccccgcttcc ttccccatcc aaggaggagg agggactaag ggctcaggtg cgggacctgg aggagaaact agagaccctg agactgaaac gggcagaaga caaagcaaag ctaaaagagc tggagaaaca caaaatccag ctggagcagg tgcaggaatg gaagagcaaa atgcaggagc agcaggccga cctgcagcgg cgcctcaagg aggcgagaaa ggaagccaag gaggcgctgg aggcaaagga acgctatatg gaggagatgg ctgatactgc tgatgccatt gagatggcca ctttggacaa ggagatggct gaagagcggg ctgagtccct gcagcaggag gtggaggcac tgaaggagcg ggtggacgag ctcactactg acttagagat cctcaaggct gagattgaag agaagggctc agatggcgct gcatccagtt atcagctcaa gcagcttgag gagcagaatg cccgcctgaa ggatgccctg gtgaggatgc gggatctttc ttcctcagag aagcaggagc atgtgaagct ccagaagctc atggaaaaga agaaccaaga gctggaagtt gtgaggcaac agcgggagcg tctgcaggag gagctaagcc aggcagagag caccattgat gagctcaagg agcaggtgga tgctgctctg ggtgctgagg agatggtgga gatgctgaca gatcggaacc tgaatctgga agagaaagtg cgcgagttga gggagactgt gggagacttg gaagcgatga atgagatgaa cgatgagctg caggagaatg cacgtgagac agaactggag ctgcgggagc agctggacat ggcaggcgcg cgggttcgtg aggcccagaa gcgtgtggag gcagcccagg agacggttgc agactaccag cagaccatca agaagtaccg ccagctgacc gccaatctac aggatgtgaa tcgggaactg acaaaccagc aggaagcatc tgtggagagg caacagcagc cacctccaga gacctttgac ttcaaaatca agtttgctga gactaaggcc catgccaagg caattgagat ggaattgagg cagatggagg tggcccaggc caatcgacac atgtccctgc tgacagcctt catgcctgac agcttccttc ggccaggtgg ggaccatgac tgcgttctgg tgctgttgct catgcctcgt ctcatttgca gggcagagct gatccggaag caggcccagg agaagtttga actaagtgag aactgttcag agcggcctgg gctgcgagga gctgctgggg agcaactcag ctttgctgct ggactggtgt actcgctgag cctgctgcag gccacgctac accgctatga gcatgccctc tctcagtgca gtgtggatgt gtataagaaa gtgggcagcc tgtaccctga gatgagtgcc catgagcgct ccttggattt cctcattgaa ctgctgcaca aggatcagct ggatgagact gtcaatgtgg agcctctcac caaggccatc aagtactatc agcatctgta cagcatccac cttgccgaac agcctgagga ctgtactatg cagctggctg accacattaa gttcacgcag agtgctctgg actgcatgag tgtggaggta ggacggctgc gtgccttctt gcagggtggg caggaggcta cagatattgc cctcctgctc cgggatctgg aaacttcatg cagtgacatc cgccagttct gcaagaagat ccgaaggcga atgccaggga cagatgctcc tgggatccca gctgcactgg cctttggacc acaggtatct gacacgctcc tagactgcag gaaacacttg acgtgggtcg tggctgtgct gcaggaggtg gcagctgctg ctgcccagct cattgcccca ctggcagaga atgaggggct acttgtggct gctctggagg aactggcttt caaagcaagc gagcagatct atgggacccc ctccagcagc ccctatgagt gtctgcgcca gtcatgcaac atcctcatca gtaccatgaa caagctggcc acagccatgc aggaggggga gtatgatgca gagcggcccc ccagcaagcc tccaccggtt gaactgcggg ctgctgccct tcgtgcagag atcacagatg ctgaaggcct gggtttgaag ctcgaagatc gagagacagt tattaaggag ttgaagaagt cactcaagat taagggagag gagctaagtg aggccaatgt gcggctgagc ctcctggaga agaagttgga cagtgctgcc aaggatgcag atgagcgcat cgagaaagtc cagactcggc tggaggagac ccaggcactg ctgcgaaaga aggagaaaga gtttgaggag acaatggatg cactccaggc tgacatcgac cagctggagg cagagaaggc agaactaaag cagcgtctga acagccagtc caaacgcacg attgagggac tccggggccc tcctccttca ggcattgcta ctctggtctc tggcattgct ggtggagcca tccctgggca ggctccaggg tctgtgccag gcccagggct ggtgaaggac tcaccactgc tgcttcagca gatctctgcc atgaggctgc acatctccca gctccagcat gagaacagca tcctcaaggg agcccagatg aaggcatcct tggcatccct gccccctctg catgttgcaa agctatccca tgagggccct ggcagtgagt taccagctgg agcgctgtat cgtaagacca gccagctgct ggagacattg aatcaattga gcacacacac gcacgtagta gacatcactc gcaccagccc tgctgccaag agcccgtcgg cccaacttat ggagcaagtg gctcagctta agtccctgag tgacaccgtc gagaagctca aggatgaggt cctcaaggag acagtatctc agcgccctgg agccacagta cccactgact ttgccacctt cccttcatca gccttcctca gggccaagga ggagcagcag gatgacacag tctacatggg caaagtgacc ttctcatgtg cggctggttt tggacagcga caccggctgg tgctgaccca ggagcagctg caccagcttc acattcgcct catctcctaa
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of DCTN1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for DCTN1. It may not necessarily be applicable to this product.
NCBI Accession #
BC071583
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UniProt Secondary Accession #
O95296; Q6IQ37; Q9BRM9; Q9UIU1; Q9UIU2; A8MY36; B4DM45; E9PFS5; E9PGE1; G5E9H4[Other Products]
UniProt Related Accession #
Q14203[Other Products]
Molecular Weight
140,887 Da
NCBI Official Full Name
Homo sapiens dynactin 1 (p150, glued homolog, Drosophila), mRNA
NCBI Official Synonym Full Names
dynactin subunit 1
NCBI Official Symbol
DCTN1 [Similar Products]
NCBI Official Synonym Symbols
P135; DP-150; DAP-150
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NCBI Protein Information
dynactin subunit 1
UniProt Protein Name
Dynactin subunit 1
UniProt Synonym Protein Names
150 kDa dynein-associated polypeptide; DAP-150; DP-150; p135; p150-glued
UniProt Gene Name
DCTN1 [Similar Products]
UniProt Synonym Gene Names
DP-150 [Similar Products]
UniProt Entry Name
DCTN1_HUMAN
NCBI Summary for DCTN1
This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA). [provided by RefSeq, Oct 2008]
UniProt Comments for DCTN1
dynactin 1: Required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. Dynein- dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles. Defects in DCTN1 are the cause of distal hereditary motor neuronopathy type 7B (HMN7B); also known as progressive lower motor neuron disease (PLMND). HMN7B is a neuromuscular disorder. Distal hereditary motor neuronopathies constitute a heterogeneous group of neuromuscular disorders caused by selective degeneration of motor neurons in the anterior horn of the spinal cord, without sensory deficit in the posterior horn. The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss. The disease starts with weakness and wasting of distal muscles of the anterior tibial and peroneal compartments of the legs. Later on, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs. Defects in DCTN1 are a cause of susceptibility to amyotrophic lateral sclerosis (ALS). ALS is a neurodegenerative disorder affecting upper and lower motor neurons, and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology is likely to be multifactorial, involving both genetic and environmental factors. Defects in DCTN1 are the cause of Perry syndrome (PERRYS); also called parkinsonism with alveolar hypoventilation and mental depression. Perry syndrome is a neuropsychiatric disorder characterized by mental depression not responsive to antidepressant drugs or electroconvulsive therapy, sleep disturbances, exhaustion and marked weight loss. Parkinsonism develops later and respiratory failure occurred terminally. Belongs to the dynactin 150 kDa subunit family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Motor; Microtubule-binding
Chromosomal Location of Human Ortholog: 2p13
Cellular Component: centrosome; cytoplasm; cytosol; kinetochore; membrane; microtubule; retromer complex; spindle pole
Molecular Function: protein binding
Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; ER to Golgi vesicle-mediated transport; G2/M transition of mitotic cell cycle; retrograde transport, endosome to Golgi
Disease: Amyotrophic Lateral Sclerosis 1; Neuronopathy, Distal Hereditary Motor, Type Viib; Perry Syndrome
Research Articles on DCTN1
1. Study shows p150glued located at the centrosome in a cell cycle-dependent manner where it is abundant during G1/S phase, located in the minus-end of microtubules during G2/M phase and at the minus-end of microtubules in the mitotic phase.
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Disclaimer
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