Product Name
COL10A1, Polyclonal Antibody
Full Product Name
COL10A1, NT (COL10A1, Collagen alpha-1(X) chain)
Product Synonym Names
Anti -COL10A1, NT (COL10A1, Collagen alpha-1(X) chain)
Product Gene Name
anti-COL10A1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 6; NC_000006.11 (116440085..116447296, complement). Location: 6q21-q22
3D Structure
ModBase 3D Structure for Q03692
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Immunogen
COL10A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 28-58 amino acids from the N-terminal region of human COL10A1.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-COL10A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-COL10A1 antibody
This gene encodes the alpha chain of type X collagen, a short chain collagen expressed by hypertrophic chondrocytes during endochondral ossification. Unlike type VIII collagen, the other short chain collagen, type X collagen is a homotrimer. Mutations in this gene are associated with Schmid type metaphyseal chondrodysplasia (SMCD) and Japanese type spondylometaphyseal dysplasia (SMD).
Product Categories/Family for anti-COL10A1 antibody
Antibodies; Abs to Collagen
Applications Tested/Suitable for anti-COL10A1 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-COL10A1 antibody
Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
NCBI/Uniprot data below describe general gene information for COL10A1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000484.2
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NCBI GenBank Nucleotide #
NM_000493.3
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UniProt Primary Accession #
Q03692
[Other Products]
UniProt Secondary Accession #
A1L4P2[Other Products]
UniProt Related Accession #
Q03692[Other Products]
Molecular Weight
66,158 Da[Similar Products]
NCBI Official Full Name
collagen alpha-1(X) chain
NCBI Official Synonym Full Names
collagen, type X, alpha 1
NCBI Official Symbol
COL10A1 [Similar Products]
NCBI Protein Information
collagen alpha-1(X) chain; collagen alpha-1(X) chain; collagen X, alpha-1 polypeptide; Schmid metaphyseal chondrodysplasia
UniProt Protein Name
Collagen alpha-1(X) chain
UniProt Gene Name
COL10A1 [Similar Products]
UniProt Entry Name
COAA1_HUMAN
NCBI Summary for COL10A1
This gene encodes the alpha chain of type X collagen, a short chain collagen expressed by hypertrophic chondrocytes during endochondral ossification. Unlike type VIII collagen, the other short chain collagen, type X collagen is a homotrimer. Mutations in this gene are associated with Schmid type metaphyseal chondrodysplasia (SMCD) and Japanese type spondylometaphyseal dysplasia (SMD). [provided by RefSeq, Jul 2008]
UniProt Comments for COL10A1
Function: Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage.
Subunit structure: Homotrimer.
Subcellular location: Secreted › extracellular space › extracellular matrix
By similarity.
Post-translational modification: Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
Involvement in disease: Schmid type metaphyseal chondrodysplasia (SMCD) [MIM:156500]: Dominantly inherited disorder of the osseous skeleton. The cardinal features of the phenotype are mild short stature, coxa vara and a waddling gait. Radiography usually shows sclerosis of the ribs, flaring of the metaphyses, and a wide irregular growth plate, especially of the knees. A variant form of SMCD is spondylometaphyseal dysplasia Japanese type. It is characterized by spinal involvement comprising mild platyspondyly, vertebral body abnormalities, and end-plate irregularity.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.12 Ref.13 Ref.14 Ref.15 Ref.16 Ref.17 Ref.19 Ref.20
Sequence similarities: Contains 1 C1q domain.
Research Articles on COL10A1
1. The results show that COL10A1 is a tumor biomarker upregulated in a wide variety of tumors including those of the breast, colon, bladder, stomach, esophagus, lung, testis, ovary and pancreas.
Precautions
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