HIV-1 Tat Interacting Protein, 60kD, Monoclonal Antibody

Anti -HIV-1 Tat Interacting Protein, 60kD (HTATIP, HTATIP1, cPLA2-interacting Protein, ESA1, PLIP, TIP60)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 11; NC_000011.9 (65479489..65487075). Location: 11q13

Monoclonal

IgG1

8C182

Mouse

Recognizes human HIV-1 Tat Interacting Protein at ~60kD.

Affinity Purified
Purified by Protein G affinity chromatography.

Supplied as a sterile-filtered liquid in PBS, pH 7.4, 1% BSA, 0.05% sodium azide.

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Small volumes of anti-KAT5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Antibodies; Abs to Transcription Factors

Western Blot (WB), Immunocytochemistry (ICC)

Suitable for use in Western Blot and Immunocytochemistry.

58,582 Da[Similar Products]

K(lysine) acetyltransferase 5

histone acetyltransferase KAT5; OTTHUMP00000233811; OTTHUMP00000233812; OTTHUMP00000233813; OTTHUMP00000233848; K-acetyltransferase 5; cPLA2 interacting protein; lysine acetyltransferase 5; cPLA(2)-interacting protein; 60 kDa Tat-interactive protein; Tat interacting protein, 60kDa; histone acetyltransferase HTATIP; HIV-1 Tat interactive protein, 60kDa

Histone acetyltransferase KAT5

HTATIP; TIP60  [Similar Products]

KAT5_HUMAN

The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq]

Tip60: a histone acetyl transferase (HAT) of the MYST family. Originally isolated as an HIV-1 TAT-interactive protein. Plays an important role in regulating chromatin remodeling, transcription and other nuclear processes by acetylating nuclear proteins. Plays a role in DNA repair and apoptosis. Three splice variants have been described.

Protein type: Nucleolus; EC 2.3.1.48; Nuclear receptor co-regulator; Acetyltransferase

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: nucleoplasm; transcription factor complex; NuA4 histone acetyltransferase complex; perinuclear region of cytoplasm; nucleolus; nucleus; cytosol

Molecular Function: protein binding; histone acetyltransferase activity; androgen receptor binding; metal ion binding; transcription coactivator activity; protein complex binding

Biological Process: proteasomal ubiquitin-dependent protein catabolic process; establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; viral reproduction; positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; negative regulation of interleukin-2 production; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; double-strand break repair; regulation of growth; androgen receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; response to ionizing radiation; histone acetylation; negative regulation of transcription, DNA-dependent

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