lipin 2, ELISA Kit

Mouse Phosphatidate phosphatase LPIN2 (LPIN2) ELISA kit; KIAA0249; ; lipin 2

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of LPIN2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9322384 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the lipin 2 (LPIN2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing LPIN2. The ELISA analytical biochemical technique of the MBS9322384 kit is based on LPIN2 antibody-LPIN2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect LPIN2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, LPIN2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

99,613 Da

lipin 2

phosphatidate phosphatase LPIN2; lipin-2

Phosphatidate phosphatase LPIN2

LPIN2_MOUSE

LPIN2: Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism. Defects in LPIN2 are the cause of Majeed syndrome (MAJEEDS). An autosomal recessive syndrome characterized by chronic recurrent multifocal osteomyelitis that is of early onset with a lifelong course, congenital dyserythropoietic anemia that presents as hypochromic, microcytic anemia during the first year of life and ranges from mild to transfusion-dependent, and transient inflammatory dermatosis, often manifesting as Sweet syndrome (neutrophilic skin infiltration). Belongs to the lipin family.

Protein type: Transcription, coactivator/corepressor; Phosphatase (non-protein); EC 3.1.3.4

Cellular Component: endoplasmic reticulum membrane; membrane; endoplasmic reticulum; cytoplasm; nucleus; cytosol

Molecular Function: phosphatidate phosphatase activity; hydrolase activity; transcription coactivator activity

Biological Process: transcription, DNA-dependent; dephosphorylation; regulation of transcription, DNA-dependent; triacylglycerol biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; lipid metabolic process; fatty acid catabolic process; fatty acid metabolic process

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