Lpin2, Polyclonal Antibody

Anti -Lpin2 (Lipin-2, LPIN2, KIAA0249, Phosphatidate Phosphatase LPIN2)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 17; NC_000083.6 (71183978..71249818). Location: 17 E1.3; 17

Polyclonal

IgG

Rabbit

Recognizes mouse Lipin 2. Species Crossreactivity: human and rat.

Affinity Purified
Purified by affinity chromatography.

Supplied as a liquid in PBS, 0.5% BSA, 0.01% thimerosal, 30% glycerol.

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Small volumes of anti-Lpin2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Lipin 2 is a nuclear protein that belongs to the evolutionarily conserved Lipin family. Studies show that a mutation to human Lipin 2 is linked to autosomal dominant high grade myopia and Majeed syndrome.

Antibodies; Abs to Cancer Markers

Western Blot (WB)

Suitable for use in Western Blot.
Dilution: Western Blot: 0.5-4ug/ml

99,613 Da[Similar Products]

lipin 2

phosphatidate phosphatase LPIN2; lipin-2

Phosphatidate phosphatase LPIN2

LPIN2_MOUSE

LPIN2: Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism. Defects in LPIN2 are the cause of Majeed syndrome (MAJEEDS). An autosomal recessive syndrome characterized by chronic recurrent multifocal osteomyelitis that is of early onset with a lifelong course, congenital dyserythropoietic anemia that presents as hypochromic, microcytic anemia during the first year of life and ranges from mild to transfusion-dependent, and transient inflammatory dermatosis, often manifesting as Sweet syndrome (neutrophilic skin infiltration). Belongs to the lipin family.

Protein type: Transcription, coactivator/corepressor; Phosphatase (non-protein); EC 3.1.3.4

Cellular Component: endoplasmic reticulum membrane; membrane; endoplasmic reticulum; cytoplasm; nucleus; cytosol

Molecular Function: phosphatidate phosphatase activity; hydrolase activity; transcription coactivator activity

Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent; dephosphorylation; positive regulation of transcription from RNA polymerase II promoter; triacylglycerol biosynthetic process; fatty acid catabolic process; lipid metabolic process; fatty acid metabolic process

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