solute carrier family 35 (CMP-sialic acid transporter), member A1, Polyclonal A

solute carrier family 35 (CMP-sialic acid transporter); member A1; SLC35A1; CMPST; CST; hCST; inactive

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Antigen Affinity Purified

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of anti-SLC35A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

ELISA (EIA), Immunohistochemistry (IHC)

29,919 Da[Similar Products]

solute carrier family 35 (CMP-sialic acid transporter), member A1

CMP-sialic acid transporter; CMP-SA-Tr; CMP-Sia-Tr; solute carrier family 35 member A1; mutated CMP-sialic acid transporter A1; solute carrier family 35 (UDP-galactose transporter), member 1; solute carrier family 35 (CMP-sialic acid transporter), member 1

CMP-sialic acid transporter

CMP-SA-Tr; CMP-Sia-Tr  [Similar Products]

S35A1_HUMAN

The protein encoded by this gene is found in the membrane of the Golgi apparatus, where it transports nucleotide sugars into the Golgi. One such nucleotide sugar is CMP-sialic acid, which is imported into the Golgi by the encoded protein and subsequently glycosylated. Defects in this gene are a cause of congenital disorder of glycosylation type 2F (CDG2F). Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2009]

SLC35A1: Transports CMP-sialic acid from the cytosol into Golgi vesicles where glycosyltransferases function. Defects in SLC35A1 are the cause of congenital disorder of glycosylation type 2F (CDG2F). CDGs are a family of severe inherited diseases caused by a defect in protein N- glycosylation. They are characterized by under-glycosylated serum proteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. Belongs to the nucleotide-sugar transporter family. SLC35A subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter; Membrane protein, integral; Transporter, SLC family; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 6q15

Cellular Component: Golgi membrane; Golgi apparatus; integral to plasma membrane

Molecular Function: CMP-sialic acid transmembrane transporter activity; sugar:hydrogen ion symporter activity

Biological Process: proton transport; cellular protein metabolic process; dolichol-linked oligosaccharide biosynthetic process; carbohydrate transport; carbohydrate metabolic process; protein modification process; protein amino acid N-linked glycosylation via asparagine; CMP-sialic acid transport; post-translational protein modification; transmembrane transport

Disease: Congenital Disorder Of Glycosylation, Type Iif

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