GPR98 / VLGR1, Polyclonal Antibody

Anti-GPR98 / VLGR1 Antibody (N-Terminus) IHC-plus; GPR98; FEB4; KIAA0686; G-protein coupled receptor 98; MASS1; VLGR1b; Usher syndrome type-2C protein; USH2B; USH2C; G protein-coupled receptor 98; KIAA1943; VLGR1; Human GPR98; VLGR1

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

Human GPR98. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except ANXA3 (50%).

Immunoaffinity Purified

PBS, 0.1% sodium azide.

1 mg/ml (lot specific)

Long term: -70 degree C; Short term: +4 degree C

Small volumes of anti-GPR98 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Very Large G Protein-Coupled Receptor-1 (VLGR1) is an Orphan-A GPCR with an unknown ligand. VLGR1 consists of three expressed isoforms. VLGR1 has a large ectodomain containing multiple CALX-beta repeats that resemble regulatory domains of sodium-calcium exchanger proteins. VLGR1b, which is the only form expressed in mouse, is apparently the largest known cell-surface protein with an ectodomain containing 35 CALX- repeats and a pentraxin homology domain.

Subfamily:-Orphan-A">Family: GPCR
Subfamily: Orphan-A

Immunohistochemistry (IHC - Paraffin)

IHC-P (4 - 9 ug/ml)

Anti-GPR98 antibody IHC of human kidney, renal tubules. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-GPR98 / VLGR1 antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-GPR98 / VLGR1 antibody IHC of human brain, hippocampus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

162,038 Da

G protein-coupled receptor 98

G-protein coupled receptor 98; usher syndrome type-2C protein; very large G protein-coupled receptor 1; very large G-protein coupled receptor 1; monogenic, audiogenic seizure susceptibility 1 homolog; monogenic audiogenic seizure susceptibility protein 1 homolog

G-protein coupled receptor 98

KIAA0686; KIAA1943; MASS1; VLGR1  [Similar Products]

GPR98_HUMAN

This gene encodes a member of the G-protein coupled receptor superfamily. The encoded protein contains a 7-transmembrane receptor domain, binds calcium and is expressed in the central nervous system. Mutations in this gene are associated with Usher syndrome 2 and familial febrile seizures. Several alternatively spliced transcripts have been described. [provided by RefSeq, Jul 2008]

GPR98: Receptor that may have an important role in the development of the central nervous system. Defects in GPR98 are the cause of Usher syndrome type 2C (USH2C). USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa with sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH2 is characterized by congenital mild hearing impairment with normal vestibular responses. Defects in GPR98 may be a cause of familial febrile convulsions type 4 (FEB4); also known as familial febrile seizures 4. Febrile convulsions are seizures associated with febrile episodes in childhood without any evidence of intracranial infection or defined pathologic or traumatic cause. It is a common condition, affecting 2-5% of children aged 3 months to 5 years. The majority are simple febrile seizures (generally defined as generalized onset, single seizures with a duration of less than 30 minutes). Complex febrile seizures are characterized by focal onset, duration greater than 30 minutes, and/or more than one seizure in a 24 hour period. The likelihood of developing epilepsy following simple febrile seizures is low. Complex febrile seizures are associated with a moderately increased incidence of epilepsy. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 2; Receptor, GPCR

Chromosomal Location of Human Ortholog: 5q13

Cellular Component: cell surface; membrane; perinuclear region of cytoplasm; cytoplasm; integral to membrane; receptor complex

Molecular Function: G-protein coupled receptor activity; protein binding; myosin binding; calcium ion binding

Biological Process: nervous system development; G-protein coupled receptor protein signaling pathway; cell-cell adhesion; inner ear receptor stereocilium organization and biogenesis; sensory perception of sound; visual perception; sensory perception of light stimulus; photoreceptor cell maintenance; detection of mechanical stimulus involved in sensory perception of sound; maintenance of organ identity; neurological system process

Disease: Febrile Seizures, Familial, 4; Usher Syndrome, Type Iic

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