Product Name
c-Fgr, Polyclonal Antibody
Popular Item
Full Product Name
c-Fgr Polyclonal Antibody
Product Synonym Names
FGR; SRC2; Tyrosine-protein kinase Fgr; Gardner-Rasheed feline sarcoma viral; v-fgr) oncogene homolog; Proto-oncogene c-Fgr; p55-Fgr; p58-Fgr; p58c-Fgr
Product Gene Name
anti-c-Fgr antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P14234
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Affinity Purified
Concentration
1 mg/ml (lot specific)
Immunogen
Synthesized peptide derived from the Internal region of human c-Fgr.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-c-Fgr antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-c-Fgr antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-c-Fgr antibody
WB: 1:500-1:2000, IHC: 1:50-1:200, ELISA: 1:5000-1:20000
Western Blot (WB) of anti-c-Fgr antibody
Western Blot analysis of various cells with c-Fgr Polyclonal Antibody.
NCBI/Uniprot data below describe general gene information for c-Fgr. It may not necessarily be applicable to this product.
NCBI Accession #
CAA36437.1
[Other Products]
UniProt Primary Accession #
P14234
[Other Products]
UniProt Secondary Accession #
Q61404; Q8BGM0[Other Products]
UniProt Related Accession #
P14234[Other Products]
Molecular Weight
Calculated MW: 59
Observed MW: 55
NCBI Official Full Name
c-fgr
NCBI Official Synonym Full Names
FGR proto-oncogene, Src family tyrosine kinase
NCBI Official Symbol
Fgr [Similar Products]
NCBI Protein Information
tyrosine-protein kinase Fgr
UniProt Protein Name
Tyrosine-protein kinase Fgr
UniProt Synonym Protein Names
Proto-oncogene c-Fgr; p55-Fgr
UniProt Gene Name
Fgr [Similar Products]
UniProt Entry Name
FGR_MOUSE
UniProt Comments for c-Fgr
FGR: a non-receptor tyrosine kinase of the Src family. Contains one SH2 and one SH3 domain. Beta 2 integrin signaling induces its c-Cbl-mediated ubiquitination in adherent neutrophils. An ortholog of v-fgr feline oncogene. Mildly amplified in hormone-resistant prostate cancer. Copy number either increased or decreased in other cancers.
Protein type: EC 2.7.10.2; Protein kinase, tyrosine (non-receptor); Oncoprotein; Kinase, protein; Protein kinase, TK; Mitochondrial; TK group; Src family
Cellular Component: actin cytoskeleton; cell projection; cytoplasm; cytoskeleton; cytosol; extrinsic to internal side of plasma membrane; membrane; mitochondrial inner membrane; mitochondrion; plasma membrane
Molecular Function: ATP binding; kinase activity; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; phosphotyrosine binding; protein binding; protein kinase activity; protein kinase binding; protein-tyrosine kinase activity; transferase activity
Biological Process: cell differentiation; defense response to Gram-positive bacterium; immune system process; innate immune response; integrin-mediated signaling pathway; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of cell migration; positive regulation of cytokine secretion; positive regulation of mast cell degranulation; positive regulation of phosphoinositide 3-kinase activity; positive regulation of phosphoinositide 3-kinase cascade; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of actin cytoskeleton organization and biogenesis; regulation of cell proliferation; regulation of cell shape; regulation of innate immune response; regulation of phagocytosis; regulation of protein kinase activity; transmembrane receptor protein tyrosine kinase signaling pathway
Research Articles on c-Fgr
1. Data indicate that Src-Family Kinases Hck and Fgr regulate cytokine secretion by macrophages.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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