Full Product Name
FoxL2 (phospho Ser263) Polyclonal Antibody
Product Gene Name
anti-FoxL2 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P58012
Other Notes
Small volumes of anti-FoxL2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for FoxL2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_075555.1
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NCBI GenBank Nucleotide #
NM_023067.3
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UniProt Primary Accession #
P58012
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UniProt Secondary Accession #
Q4ZGJ3[Other Products]
UniProt Related Accession #
P58012[Other Products]
Molecular Weight
38,772 Da
NCBI Official Full Name
forkhead box protein L2
NCBI Official Synonym Full Names
forkhead box L2
NCBI Official Symbol
FOXL2 [Similar Products]
NCBI Official Synonym Symbols
BPES; PFRK; POF3; BPES1; PINTO
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NCBI Protein Information
forkhead box protein L2
UniProt Protein Name
Forkhead box protein L2
Protein Family
Forkhead box protein
UniProt Gene Name
FOXL2 [Similar Products]
NCBI Summary for FoxL2
This gene encodes a forkhead transcription factor. The protein contains a fork-head DNA-binding domain and may play a role in ovarian development and function. Expansion of a polyalanine repeat region and other mutations in this gene are a cause of blepharophimosis syndrome and premature ovarian failure 3. [provided by RefSeq, Jul 2016]
UniProt Comments for FoxL2
Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (). Is a regulator of CYP19 expression (). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2.
Research Articles on FoxL2
1. The ***** granulosa cell tumor (AGCT)-like components are likely to be tumor-like proliferations but not truly neoplastic AGCT. FOXL2 mutation testing may be useful in confirming an AGCT-like component.
Precautions
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Disclaimer
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