Ras GTPase Activating Protein 1, Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures.

Host: E Coli
Source: Prokaryotic expression

>95%

Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.

9.2 (lot specific)

Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. The loss of this protein is less than 5% within the expiration date under appropriate storage condition.

Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.

Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.

Small volumes of RASA1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

115,761 Da

ras GTPase-activating protein 1

Ras GTPase-activating protein 1

RASA; GAP; GTPase-activating protein; RasGAP  [Similar Products]

RASA1_BOVIN

RASA1: a GTPase activator for normal RAS p21 but not its oncogenic counterpart, converting it to the putatively inactive GDP-bound state. Acting as a suppressor of RAS function, it enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the s of either protein are associated with basal cell carcinomas. Two alternatively spliced isoforms have been described.

Protein type: GAPs; Motility/polarity/chemotaxis; Oncoprotein; GAPs, Ras

Cellular Component: cytoplasm

Molecular Function: GTPase binding; receptor binding

Biological Process: embryonic development; regulation of actin filament polymerization; cytokinesis after mitosis; negative regulation of Ras protein signal transduction; negative regulation of cell adhesion; negative regulation of neuron apoptosis; signal transduction; negative regulation of cell-matrix adhesion; vasculogenesis

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