Product Name
HNRNPLL, Polyclonal Antibody
Full Product Name
HNRNPLL Antibody, Biotin conjugated
Product Synonym Names
Heterogeneous nuclear ribonucleoprotein L-likehnRNPLL; Stromal RNA-regulating factor; HNRNPLL; HNRPLL; SRRF; BLOCK24
Product Gene Name
anti-HNRNPLL antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q8WVV9
Purity/Purification
>95%, Protein G purified
Immunogen
Recombinant human Heterogeneous nuclear ribonucleoprotein L-like protein (1-72AA)
Preservative
0.03% Proclin 300
Constituents
50% Glycerol, 0.01M PBS, PH 7.4
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-132712 / sc-132713 / sc-101975
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-HNRNPLL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-HNRNPLL antibody
RNA-binding protein that functions as regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC.
Applications Tested/Suitable for anti-HNRNPLL antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for HNRNPLL. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001136122.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001142650.1
[Other Products]
UniProt Primary Accession #
Q8WVV9
[Other Products]
UniProt Secondary Accession #
Q53T80; Q5JB51; Q5JB52; Q659B9; Q8IVH5; Q8IVH6; Q96HR5[Other Products]
UniProt Related Accession #
Q8WVV9[Other Products]
Molecular Weight
56,467 Da
NCBI Official Full Name
heterogeneous nuclear ribonucleoprotein L-like isoform 2
NCBI Official Synonym Full Names
heterogeneous nuclear ribonucleoprotein L like
NCBI Official Symbol
HNRNPLL [Similar Products]
NCBI Official Synonym Symbols
SRRF; HNRPLL
[Similar Products]
NCBI Protein Information
heterogeneous nuclear ribonucleoprotein L-like
UniProt Protein Name
Heterogeneous nuclear ribonucleoprotein L-like
UniProt Synonym Protein Names
Stromal RNA-regulating factor
Protein Family
Heterogeneous nuclear ribonucleoprotein
UniProt Gene Name
HNRNPLL [Similar Products]
UniProt Synonym Gene Names
HNRPLL; SRRF; hnRNPLL [Similar Products]
UniProt Entry Name
HNRLL_HUMAN
NCBI Summary for HNRNPLL
HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing of CD45 (PTPRC; MIM 151460), a tyrosine phosphatase essential for T-cell development and activation (Oberdoerffer et al., 2008 [PubMed 18669861]).[supplied by OMIM, Aug 2008]
UniProt Comments for HNRNPLL
HNRPLL: RNA-binding protein that functions as regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC. Interacts with HNRNPL. Up-regulated in stimulated T-cells. Widely expressed. Detected in bone marrow stroma cells, skeletal muscle, heart, placenta, pancreas, kidney and lung. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: RNA-binding
Chromosomal Location of Human Ortholog: 2p22.1
Cellular Component: membrane
Molecular Function: mRNA binding; protein binding
Biological Process: positive regulation of RNA splicing
Research Articles on HNRNPLL
1. Loss-of-function mutation of hnRNPLL disrupts peripheral T cell accumulation even in the absence of CD45 protein, indicating that hnRNPLL acts through an independent mechanism to promote peripheral T cell longevity.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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