Product Name
Vacuolar protein sorting-associated protein 33B (Vps33b), Recombinant Protein
Full Product Name
Recombinant Rat Vacuolar protein sorting-associated protein 33B (Vps33b)
Product Gene Name
Vps33b recombinant protein
[Similar Products]
Product Synonym Gene Name
Vps33b[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
2-617aa, Full Length of Mature Protein
Sequence
AFPHRLDAPE LPDFSMLKRL ARDQLIYLLE QLPGKKDLFI EADLMSPLDR IANVSILKQH EVDKLYKVEN KLTLSSNEQL CFLVRPRIKT MRYIANLVNA DKLAGRVRKY KIILSPQKFY ACEMVLEEEG VYGDVSCDEW AFSLLPLDVD LLSMELPEFF RDYFLEGDQR WINTVAQALH LLSTLYGPFP NCYGIGRCTK MSYDLWRKLE EEEDSETKGR RPEIGHIFLL DRDVDFVTAL CSQVVYEGLV DDTFRIKCGS VDFGPEVTSS DKSLKVLLNA EDKVFSEIRN EHFSNVFGFL SQKARNLQAQ YDRRRGMDIK QMKNFVSQEL KGLKQEHRLL SLHIGACESI MKKKTKQDFQ ELIKTEHALL EGFNIRESTS YIEEHIDRQV SPIESLRLMC LLSITENGLI PKDYRSLKTQ YLQSYGPEHL LTFSNLRRAG LLTEQASGDT LTAVENKVSK LVTDKAAGKI TDAFSSLAKR SNFRAISKKL NLIPRVDGEY DLKVPRDMAY VFSGAYVPLS CRIIEQVLDR RSWQGLDEVV RLLNCSDFAF TDMAKEDKAS SESLRLILVV FLGGCTFSEI SALRFLGREK GYRFIFLTTA VTNSARLMEA MSEVKS
3D Structure
ModBase 3D Structure for Q63616
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Vps33b recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Vps33b recombinant protein
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec-1 domain family, and encodes the human ortholog of rat Vps33b which is homologous to the yeast class C Vps33 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes
lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome
lysosome pathway.
NCBI/Uniprot data below describe general gene information for Vps33b. It may not necessarily be applicable to this product.
NCBI Accession #
NP_071622.1
[Other Products]
NCBI GenBank Nucleotide #
NM_022286.2
[Other Products]
UniProt Primary Accession #
Q63616
[Other Products]
UniProt Related Accession #
Q63616[Other Products]
Molecular Weight
70,693 Da
NCBI Official Full Name
vacuolar protein sorting-associated protein 33B
NCBI Official Synonym Full Names
VPS33B, late endosome and lysosome associated
NCBI Official Symbol
Vps33b [Similar Products]
NCBI Protein Information
vacuolar protein sorting-associated protein 33B
UniProt Protein Name
Vacuolar protein sorting-associated protein 33B
Protein Family
Vacuolar protein sorting-associated protein
UniProt Gene Name
Vps33b [Similar Products]
UniProt Synonym Gene Names
r-vps33b [Similar Products]
NCBI Summary for Vps33b
role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion [RGD, Feb 2006]
UniProt Comments for Vps33b
May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. Mediates phagolysosomal fusion in macrophages. Proposed to be involved in endosomal maturation implicating VIPAS39. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical recycling pathway and in the maintenance of the apical-basolateral polarity. Seems to be involved in the sorting of specific cargos from the trans-Golgi network to alpha-granule-destined multivesicular bodies (MVBs) promoting MVBs maturation in megakaryocytes ().
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
