Ras GTPase Activating Protein 1 (RASA1), Polyclonal Antibody

Ras-GAP; RasGAP; CM-AVM; CMAVM; GAP; PKWS; RASA; P120GAP; RAS P21 Protein Activator 1; Capillary Malformation-Arteriovenous Malformation

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

200ug/ml (lot specific)

Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.

Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.

Small volumes of anti-RASA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA)

115,440 Da

RAS p21 protein activator 1

ras GTPase-activating protein 1

Ras GTPase-activating protein 1

Rasa; GAP; GTPase-activating protein; RasGAP  [Similar Products]

may play a role in Ras GTPase mediated signal transduction; may be involved in cell proliferation and cell migration [RGD, Feb 2006]

RASA1: a GTPase activator for normal RAS p21 but not its oncogenic counterpart, converting it to the putatively inactive GDP-bound state. Acting as a suppressor of RAS function, it enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the s of either protein are associated with basal cell carcinomas. Two alternatively spliced isoforms have been described.

Protein type: GAPs; GAPs, Ras; Motility/polarity/chemotaxis; Oncoprotein

Chromosomal Location of Human Ortholog: 2q11

Cellular Component: cytosol; membrane; nuclear membrane; plasma membrane; ruffle

Molecular Function: glycoprotein binding; GTPase activator activity; GTPase binding; kinase binding; platelet-derived growth factor receptor binding; protein binding; protein complex binding; protein kinase B binding; receptor binding; receptor tyrosine kinase binding; transcription factor binding

Biological Process: blood vessel morphogenesis; cytokinesis after mitosis; male genitalia development; negative regulation of cell adhesion; negative regulation of cell-matrix adhesion; negative regulation of neuron apoptosis; negative regulation of Ras protein signal transduction; positive regulation of fibroblast proliferation; positive regulation of glucose import; positive regulation of GTPase activity; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein amino acid phosphorylation; regulation of actin filament polymerization; response to drug; response to insulin stimulus; signal transduction; vasculogenesis

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