Product Name
ANKS1B, Blocking Peptide
Full Product Name
ANKS1B Antibody (Center) Blocking peptide
Product Synonym Names
Ankyrin repeat and sterile alpha motif domain-containing protein 1B; Amyloid-beta protein intracellular domain-associated protein 1; AIDA-1; E2A-PBX1-associated protein; EB-1; ANKS1B
Product Gene Name
ANKS1B blocking peptide
[Similar Products]
Antibody/Peptide Pairs
ANKS1B peptide (MBS9219906) is used for blocking the activity of ANKS1B antibody (MBS9201353)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q7Z6G8
Specificity
The synthetic peptide sequence used to generate the antibody was selected from the Center region of ANKS1B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Cellular Location
Cytoplasm Isoform 3: Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, dendritic spine. Nucleus. Nucleus, Cajal body. Note: The synaptic localization requires DLG4 interaction. Translocation to the nucleus in response to stimulation of NMDA receptors (NMDARs) in a calcium-independent manner (By similarity). Isoform 6: Nucleus.
Tissue Location
Highly expressed in marrow from patients with pre-B ALL associated with the t(1;19) translocation. Strongly expressed in brain and testis. Expressed in fetal brain. Isoform 4 is highly expressed in brain (at protein level). Isoform 6 is expressed in brain and several cancer cell lines
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Other Notes
Small volumes of ANKS1B blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
ANKS1B blocking peptide
Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells. Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing.
NCBI/Uniprot data below describe general gene information for ANKS1B. It may not necessarily be applicable to this product.
NCBI Accession #
Q7Z6G8.2
[Other Products]
UniProt Primary Accession #
Q7Z6G8
[Other Products]
UniProt Secondary Accession #
Q5XLJ0; Q6IVB5; A5PKY5; A7E259; A8K153; A8MSN4; B4DFP6; B4DH98; F8VPM3; F8VZR9; F8WC27[Other Products]
UniProt Related Accession #
Q7Z6G8[Other Products]
Molecular Weight
44,522 Da
NCBI Official Full Name
Ankyrin repeat and sterile alpha motif domain-containing protein 1B
NCBI Official Synonym Full Names
ankyrin repeat and sterile alpha motif domain containing 1B
NCBI Official Symbol
ANKS1B [Similar Products]
NCBI Official Synonym Symbols
EB1; AIDA; EB-1; ANKS2; AIDA-1; cajalin-2
[Similar Products]
NCBI Protein Information
ankyrin repeat and sterile alpha motif domain-containing protein 1B
UniProt Protein Name
Ankyrin repeat and sterile alpha motif domain-containing protein 1B
UniProt Synonym Protein Names
Amyloid-beta protein intracellular domain-associated protein 1; AIDA-1; E2A-PBX1-associated protein; EB-1
Protein Family
Ankyrin repeat and sterile alpha motif domain-containing protein
UniProt Gene Name
ANKS1B [Similar Products]
UniProt Synonym Gene Names
AIDA-1; EB-1 [Similar Products]
UniProt Entry Name
ANS1B_HUMAN
NCBI Summary for ANKS1B
This gene encodes a multi-domain protein that is predominantly expressed in brain and testis. This protein interacts with amyloid beta protein precursor (AbetaPP) and may have a role in normal brain development, and in the pathogenesis of Alzheimer's disease. Expression of this gene has been shown to be elevated in patients with pre-B cell acute lymphocytic leukemia associated with t(1;19) translocation. Alternatively spliced transcript variants encoding different isoforms (some with different subcellular localization, PMID:15004329) have been described for this gene. [provided by RefSeq, Aug 2011]
UniProt Comments for ANKS1B
AIDA-1b: Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells. 8 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell adhesion
Chromosomal Location of Human Ortholog: 12q23.1
Molecular Function: ephrin receptor binding
Research Articles on ANKS1B
1. We provide the first evidence that ANKS1B expression is down regulated in ccRCC tumors relative to patient-matched normal kidney tissue in smokers.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
