ANKS1B, Polyclonal Antibody

Ankyrin repeat and sterile alpha motif domain-containing protein 1B; Amyloid-beta protein intracellular domain-associated protein 1; AIDA-1; E2A-PBX1-associated protein; EB-1; ANKS1B

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Antigen Affinity Purified

Liquid

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of anti-ANKS1B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Western blot
All lanes: ANKS1B antibody at 5.28ug/ml
Lane 1: 293T whole cell lysate
Lane 2: HepG-2 whole cell lysate
Lane 3: Hela whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 139,49,58,53,52,86,48,41,29,45 kDa
Observed band size: 138 kDa

Immunohistochemistry of paraffin-embedded human testis tissue MBS7046522 at dilution 1:100

Immunohistochemistry of paraffin-embedded human brain tissue MBS7046522 at dilution 1:100

44,522 Da

ankyrin repeat and sterile alpha motif domain containing 1B

ankyrin repeat and sterile alpha motif domain-containing protein 1B

Ankyrin repeat and sterile alpha motif domain-containing protein 1B

AIDA-1; EB-1  [Similar Products]

ANS1B_HUMAN

This gene encodes a multi-domain protein that is predominantly expressed in brain and testis. This protein interacts with amyloid beta protein precursor (AbetaPP) and may have a role in normal brain development, and in the pathogenesis of Alzheimer's disease. Expression of this gene has been shown to be elevated in patients with pre-B cell acute lymphocytic leukemia associated with t(1;19) translocation. Alternatively spliced transcript variants encoding different isoforms (some with different subcellular localization, PMID:15004329) have been described for this gene. [provided by RefSeq, Aug 2011]

AIDA-1b: Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion

Chromosomal Location of Human Ortholog: 12q23.1

Molecular Function: ephrin receptor binding

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