Full Product Name
ATP7B Antibody
Product Synonym Names
WD; PWD; WC1; WND
Product Gene Name
anti-ATP7B antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P35670
Species Reactivity
Human, Mouse, Rat
Specificity
ATP7B Antibody detects endogenous levels of total ATP7B
Purity/Purification
Immunogen affinity purified
Form/Format
In phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
Recombinant protein of human ATP7B
Preparation and Storage
Store at-20 degree C for 1 year
Other Notes
Small volumes of anti-ATP7B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ATP7B antibody
This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-s. This protein functions as a monomer, exporting copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease (WD).
Applications Tested/Suitable for anti-ATP7B antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-ATP7B antibody
WB: 1:500-1:2000
IHC: 1:50-1:200
Western Blot (WB) of anti-ATP7B antibody
Western blot analysis of extracts of various celllines, using ATP7B antibody.
NCBI/Uniprot data below describe general gene information for ATP7B. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000044.2
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NCBI GenBank Nucleotide #
NM_000053.3
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UniProt Primary Accession #
P35670
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UniProt Secondary Accession #
Q16318; Q16319; Q4U3V3; Q59FJ9; Q5T7X7[Other Products]
UniProt Related Accession #
P35670[Other Products]
NCBI Official Full Name
copper-transporting ATPase 2 isoform a
NCBI Official Synonym Full Names
ATPase copper transporting beta
NCBI Official Symbol
ATP7B [Similar Products]
NCBI Official Synonym Symbols
WD; PWD; WC1; WND
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NCBI Protein Information
copper-transporting ATPase 2
UniProt Protein Name
Copper-transporting ATPase 2
UniProt Synonym Protein Names
Copper pump 2; Wilson disease-associated protein
UniProt Gene Name
ATP7B [Similar Products]
UniProt Synonym Gene Names
PWD; WC1; WND [Similar Products]
NCBI Summary for ATP7B
This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-s. This protein functions as a monomer, exporting copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease (WD). [provided by RefSeq, Jul 2008]
UniProt Comments for ATP7B
Copper ion transmembrane transporter involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile.
Research Articles on ATP7B
1. for ATP7B mutations, the more severe impact on ATP7B protein was, the younger onset age and lower Cp level presented. The feasibility of presymptomatic DNA diagnosis and predicting clinical manifestation or severity of Wilson disease (WD) would be facilitated with identified mutations and genotype-phenotype correlation precisely revealed in the study.
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Disclaimer
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