Full Product Name
JARID1B Antibody
Product Synonym Names
Mouse monoclonal IgG to JARID1B
Product Gene Name
anti-JARID1B antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9UGL1
Purity/Purification
Protein G-Sepharose affinity purified.
Immunogen
Recombinant fragment of Human JARID1B (N-terminus)
Preservative
0.02% Sodium Azide and 50% glycerol, 1% BSA, PBS, pH7.4.
Cellular Localization
Nucleus
Preparation and Storage
Aliquot and store at-20 degree C. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of anti-JARID1B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-JARID1B antibody
Histone demethylase JARID1B (EC 1.14.11.-) (Jumonji/ARID domain-containing protein 1B) (PLU-1) (Retinoblastoma-binding protein 2 homolog 1) (RBP2-H1) (Cancer/testis antigen 31) (CT31).
Product Categories/Family for anti-JARID1B antibody
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
Applications Tested/Suitable for anti-JARID1B antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-JARID1B antibody
ELISA: 1:5000-1:20000
WB: 1:100-1:2000
Testing Data of anti-JARID1B antibody
JARID1B (N-terminus) antibody at 1/2000 dilution interacts with recombinant i JARID1B protein with a GST tag. Predicted band size: 46KDa. Observed band size: 46KDa.
NCBI/Uniprot data below describe general gene information for JARID1B. It may not necessarily be applicable to this product.
NCBI Accession #
NP_006609.3
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NCBI GenBank Nucleotide #
NM_006618
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UniProt Primary Accession #
Q9UGL1
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UniProt Secondary Accession #
O95811; Q15752; Q9Y3Q5[Other Products]
UniProt Related Accession #
Q9UGL1[Other Products]
Molecular Weight
179,409 Da
NCBI Official Full Name
lysine-specific demethylase 5B isoform 2
NCBI Official Synonym Full Names
lysine demethylase 5B
NCBI Official Symbol
KDM5B [Similar Products]
NCBI Official Synonym Symbols
CT31; PLU1; PUT1; PLU-1; JARID1B; PPP1R98; RBP2-H1; RBBP2H1A
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NCBI Protein Information
lysine-specific demethylase 5B
UniProt Protein Name
Lysine-specific demethylase 5B
UniProt Synonym Protein Names
Cancer/testis antigen 31; CT31; Histone demethylase JARID1B; Jumonji/ARID domain-containing protein 1B; PLU-1; Retinoblastoma-binding protein 2 homolog 1; RBP2-H1
UniProt Gene Name
KDM5B [Similar Products]
UniProt Synonym Gene Names
JARID1B; PLU1; RBBP2H1; CT31; RBP2-H1 [Similar Products]
NCBI Summary for JARID1B
This gene encodes a lysine-specific histone demethylase that belongs to the jumonji/ARID domain-containing family of histone demethylases. The encoded protein is capable of demethylating tri-, di- and monomethylated lysine 4 of histone H3. This protein plays a role in the transcriptional repression or certain tumor suppressor genes and is upregulated in certain cancer cells. This protein may also play a role in genome stability and DNA repair. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]
UniProt Comments for JARID1B
Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:24952722, PubMed:27214403, PubMed:28262558). Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5 (PubMed:24952722). In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 ().
Research Articles on JARID1B
1. HBx activates the histone demethylase KDM5B and induces hepatic progenitor cell-like features in hepatocellular carcinoma
Precautions
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Disclaimer
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