Full Product Name
VPS33B Antibody
Product Gene Name
anti-VPS33B antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Other Notes
Small volumes of anti-VPS33B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Testing Data of anti-VPS33B antibody
Testing Data #2 of anti-VPS33B antibody
NCBI/Uniprot data below describe general gene information for VPS33B. It may not necessarily be applicable to this product.
NCBI Accession #
BC016445
[Other Products]
UniProt Secondary Accession #
Q96K14; Q9NRP6; Q9NSF3; B3KQF6[Other Products]
UniProt Related Accession #
Q9H267[Other Products]
Molecular Weight
60,032 Da
NCBI Official Full Name
Homo sapiens vacuolar protein sorting 33 homolog B (yeast), mRNA
NCBI Official Synonym Full Names
VPS33B, late endosome and lysosome associated
NCBI Official Symbol
VPS33B [Similar Products]
NCBI Protein Information
vacuolar protein sorting-associated protein 33B
UniProt Protein Name
Vacuolar protein sorting-associated protein 33B
Protein Family
Vacuolar protein sorting-associated protein
UniProt Gene Name
VPS33B [Similar Products]
UniProt Synonym Gene Names
hVPS33B [Similar Products]
NCBI Summary for VPS33B
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec-1 domain family, and encodes the human ortholog of rat Vps33b which is homologous to the yeast class C Vps33 protein. The mammalian class C vacuolar protein sorting proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Mutations in this gene are associated with arthrogryposis-renal dysfunction-cholestasis syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
UniProt Comments for VPS33B
May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. Mediates phagolysosomal fusion in macrophages (PubMed:18474358). Proposed to be involved in endosomal maturation implicating VIPAS39. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical recycling pathway and in the maintenance of the apical-basolateral polarity (PubMed:20190753). Seems to be involved in the sorting of specific cargos from the trans-Golgi network to alpha-granule-destined multivesicular bodies (MVBs) promoting MVBs maturation in megakaryocytes ().
Research Articles on VPS33B
1. ARKID syndrome is caused by VPS33B mutation.
Precautions
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