Full Product Name
Mouse Anti-Human IGF-1
Product Synonym Names
IGF1; IGFI; IGF-I; IGF1A
Product Gene Name
anti-IGF-1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 12; NC_000012.12 (102395867..102480600, complement). Location: 12q23.2
3D Structure
ModBase 3D Structure for P05019
Antibody Generation
This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of IGF-I.
Reconstitution
Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml.
Preparation and Storage
Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-IGF-1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-IGF-1 antibody
Insulin-like growth factor (IGF)-I (also known as somatomedin C and somatomedin A) and IGF-II (multiplication stimulating activity or MSA) belong to the family of insulin-like growth factors that are structurally homologous to proinsulin. Mature IGF-I and IGF-II share approximately 70% sequence identity. Both IGF-I and IGF-II are expressed in many tissues and cell types and may have autocrine, paracrine and endocrine functions. Mature IGF-I and IGF-II are highly conserved between the human, bovine and porcine proteins (100% identity), and exhibit cross-species activity.
Applications Tested/Suitable for anti-IGF-1 antibody
Western Blot (WB)
NCBI/Uniprot data below describe general gene information for IGF-1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000609.1
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NCBI GenBank Nucleotide #
NM_000618.3
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UniProt Primary Accession #
P05019
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UniProt Secondary Accession #
P01343; Q14620; B2RWM7; E9PD02[Other Products]
UniProt Related Accession #
P05019[Other Products]
Molecular Weight
21,841 Da
NCBI Official Full Name
insulin-like growth factor I isoform 4 preproprotein
NCBI Official Synonym Full Names
insulin-like growth factor 1 (somatomedin C)
NCBI Official Symbol
IGF1 [Similar Products]
NCBI Official Synonym Symbols
IGFI; IGF-I; IGF1A
[Similar Products]
NCBI Protein Information
insulin-like growth factor I; MGF; IGF-IA; IGF-IB; somatomedin-C; mechano growth factor; insulin-like growth factor IA; insulin-like growth factor IB
UniProt Protein Name
Insulin-like growth factor I
UniProt Synonym Protein Names
Mechano growth factor; MGF; Somatomedin-C
UniProt Gene Name
IGF1 [Similar Products]
UniProt Synonym Gene Names
IBP1; IGF-I; MGF [Similar Products]
UniProt Entry Name
IGF1_HUMAN
NCBI Summary for IGF-1
The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]
UniProt Comments for IGF-1
Function: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ref.17
Subcellular location: Secreted.
Involvement in disease: Insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:608747]: Autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.Note: The disease is caused by mutations affecting the gene represented in this entry.
Sequence similarities: Belongs to the insulin family.
Sequence caution: The sequence CAA27250.1 differs from that shown. Reason: Erroneous gene model prediction.
Research Articles on IGF-1
1. Delivery of the E-peptide ameliorated the decline in function and resulted in significant preservation of cardiac contractility.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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