Full Product Name
TPI1, CT (Triosephosphate Isomerase, TIM, Triose-phosphate Isomerase, TPI)
Product Synonym Names
Anti -TPI1, CT (Triosephosphate Isomerase, TIM, Triose-phosphate Isomerase, TPI)
Product Gene Name
anti-TPI1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 12; NC_000012.11 (6976584..6980110). Location: 12p13
3D Structure
ModBase 3D Structure for P60174
Species Reactivity
Human, Mouse
Specificity
Recognizes human TPI1. Species Crossreactivity: mouse.
Purity/Purification
Purified
Purified by ammonium sulfate precipitation.
Form/Format
Supplied as a liquid in PBS, 0.102% sodium azide.
Immunogen
Synthetic peptide selected from the C-terminal region of human TPI1 (KLH).
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-TPI1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TPI1 antibody
TPI1 is an enzyme, consisting of two identical proteins, which catalyzes the isomerization of glyceraldehydes 3-phosphate (G3P) and dihydroxy-acetone phosphate (DHAP) in glycolysis and gluconeogenesis.
Product Categories/Family for anti-TPI1 antibody
Antibodies; Abs to Enzymes, Isomerase
Applications Tested/Suitable for anti-TPI1 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-TPI1 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100
NCBI/Uniprot data below describe general gene information for TPI1. It may not necessarily be applicable to this product.
UniProt Primary Accession #
P60174
[Other Products]
UniProt Secondary Accession #
P00938; Q6FHP9; Q6IS07; Q8WWD0; Q96AG5[Other Products]
UniProt Related Accession #
P60174; Q53HE2[Other Products]
Molecular Weight
26,669 Da[Similar Products]
NCBI Official Full Name
TPI1
NCBI Official Synonym Full Names
triosephosphate isomerase 1
NCBI Official Symbol
TPI1 [Similar Products]
NCBI Official Synonym Symbols
TIM; TPI; MGC88108
[Similar Products]
NCBI Protein Information
triosephosphate isomerase; OTTHUMP00000165244; triose-phosphate isomerase
UniProt Protein Name
Triosephosphate isomerase
UniProt Synonym Protein Names
Triose-phosphate isomerase
UniProt Gene Name
TPI1 [Similar Products]
UniProt Synonym Gene Names
TPI [Similar Products]
UniProt Entry Name
TPIS_HUMAN
NCBI Summary for TPI1
This gene encodes an enzyme, consisting of two identical proteins, which catalyzes the isomerization of glyceraldehydes 3-phosphate (G3P) and dihydroxy-acetone phosphate (DHAP) in glycolysis and gluconeogenesis. Mutations in this gene are associated with triosephosphate isomerase deficiency. Pseudogenes have been identified on chromosomes 1, 4, 6 and 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq]
UniProt Comments for TPI1
TPI1: Defects in TPI1 are the cause of triosephosphate isomerase deficiency (TPI deficiency). TPI deficiency is an autosomal recessive disorder. It is the most severe clinical disorder of glycolysis. It is associated with neonatal jaundice, chronic hemolytic anemia, progressive neuromuscular dysfunction, cardiomyopathy and increased susceptibility to infection. Belongs to the triosephosphate isomerase family. 2 isoforms of the human protein are produced by alternative promoter.
Protein type: Carbohydrate Metabolism - glycolysis and gluconeogenesis; Isomerase; Carbohydrate Metabolism - inositol phosphate; Carbohydrate Metabolism - fructose and mannose; EC 5.3.1.1
Chromosomal Location of Human Ortholog: 12p13
Cellular Component: extracellular space; nucleus; cytosol
Molecular Function: protein binding; triose-phosphate isomerase activity
Biological Process: pentose-phosphate shunt; glycolysis; multicellular organismal development; carbohydrate metabolic process; glucose metabolic process; pathogenesis; gluconeogenesis
Disease: Triosephosphate Isomerase Deficiency
Research Articles on TPI1
1. structural changes rather than abnormal catalysis may play an important role in the clinical manifestations of TPI deficiency; the postulated high aggregation ability of the unstable Glu104Asp mutant would lead to more serious symptoms
Precautions
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Disclaimer
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